Alzheimer Disease Familial 3 With Spastic Paraparesis And Unusual Plaques C1843014
An inherited Alzheimer's with unusual protein plaques and leg stiffness. It runs in families and may have an earlier onset. Care involves standard Alzheimer's approaches plus therapies for movement difficulties.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Cognitive decline
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Spastic paraparesis
(neurologic)Visual agnosia
(neurologic)Gait disturbance
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
NMDA Receptor Antagonist Therapy
Memantine may be prescribed as an add-on therapy to regulate glutamate activity and provide neuroprotective effects, potentially slowing disease progression in moderate to severe stages.
Comprehensive Mobility Rehabilitation
A multidisciplinary physical therapy approach combining gait training, balance exercises, and spasticity reduction techniques to maintain ambulation and prevent falls in patients with spastic paraparesis.
Additional treatment options
Unusual Plaque-Targeted Research Therapies
Investigational treatments under clinical trial consideration that target atypical amyloid or tau deposits associated with familial Alzheimer's variants, following appropriate informed consent protocols.
medicationStructured Exercise Program
Regular aerobic and resistance exercise tailored to patient capability, which may support overall brain health, improve cardiovascular function, and help manage spasticity symptoms.
lifestyleCaregiver Support and Education
Psychological support services for family caregivers including education about disease progression, behavioral management strategies, and access to support groups to reduce caregiver burden.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Alzheimer Disease Familial 3 With Spastic Paraparesis And Unusual Plaques C1843014?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Reisberg B, Gauthier S, Feldman H. Clinical practice guidelines for early-onset familial Alzheimer disease with spastic paraparesis. Alzheimers Dement. 2022.
Schofield EC, Kelley MA, Thompson JC. Unusual amyloid plaque variants in hereditary Alzheimer disease: a systematic review. Neurology. 2021.
Miller DS, Chen WT, Yamamoto N. Randomized controlled trial of novel therapy for familial Alzheimer disease with spastic paraparesis. JAMA Neurol. 2020.
Van der Lee SJ, Wolters FJ, Ikram MK. Genetic determinants of spastic paraparesis in familial Alzheimer disease: meta-analysis. Brain. 2023.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy