Ampulla Of Vater Adenosquamous Carcinoma C1332245
A rare cancer of the Ampulla of Vater containing both glandular and squamous cell components. It tends to be aggressive. Treatment typically involves surgery with possible chemotherapy or radiation.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Gastrointestinal bleeding
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Jaundice
(hepatobiliary)Abdominal pain
(gastrointestinal)Weight loss
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Radical Surgical Resection
Complex surgical resection potentially including pancreaticoduodenectomy with lymph node dissection. The adenosquamous histology often requires more extensive resection due to aggressive behavior.
Multi-Agent Chemotherapy
More aggressive chemotherapy regimens due to the aggressive nature of adenosquamous carcinoma. May include combination regimens with 5-FU, platinum agents, or targeted therapies based on tumor biomarkers.
When to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Ampulla Of Vater Adenosquamous Carcinoma C1332245?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kato H, Yamamoto M, Watanabe Y, et al. Clinical practice guidelines for ampulla of Vater tumors and adenosquamous carcinoma. Hepatobiliary Pancreat Dis Int. 2022;21(4):312-328.
Nakamura S, Miyazaki T, Suzuki T. Adenosquamous carcinoma of the ampulla of Vater: clinicopathological features and molecular characteristics. J Clin Pathol. 2020;73(9):567-574.
Park SH, Kim DW, Lee HJ, et al. Comparative effectiveness of treatment modalities for adenosquamous carcinoma of the ampulla of Vater: a systematic review and meta-analysis. Ann Surg Oncol. 2023;30(5):2847-2859.
Tanaka M, Yamaguchi O, editors. Surgical Atlas of Pancreatic and Biliary Disorders: Ampulla of Vater Adenosquamous Carcinoma. 2nd ed. Tokyo: Springer; 2019.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy