Ampulla Of Vater Clear Cell Adenocarcinoma C1332246
A rare variant of adenocarcinoma in the Ampulla of Vater with clear-appearing cells under the microscope. It is uncommon and managed similarly to other Ampulla of Vater cancers with surgery and other treatments.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Painless obstructive jaundice
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Right upper quadrant abdominal pain
(gastrointestinal)Unintentional weight loss
(constitutional)New‑onset diabetes mellitus
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Radical Surgical Resection
Complete surgical removal of the tumor with adequate margins, typically via pancreaticoduodenectomy. Clear cell adenocarcinomas may have distinct characteristics affecting surgical planning.
Targeted Therapy with mTOR Inhibitors
Clear cell adenocarcinomas may respond to targeted therapies such as everolimus or sunitinib, which inhibit specific molecular pathways involved in tumor growth.
Additional treatment options
Immunotherapy
Checkpoint inhibitor therapy may be considered for tumors with specific genetic profiles or high microsatellite instability. Helps activate immune system against cancer cells.
medicationComprehensive Genetic Profiling
Molecular and genetic testing of tumor tissue to identify actionable mutations and guide personalized treatment selection.
monitoringPsychosocial Oncology Support
Counseling and psychological support services to help patients cope with cancer diagnosis and treatment, including management of anxiety, depression, and quality of life concerns.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Ampulla Of Vater Clear Cell Adenocarcinoma C1332246?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kimura W, Kuroda A, Futakawa N. Clear cell adenocarcinoma of the ampulla of Vater: a clinicopathological study. J Clin Pathol. 2016;69(7):625-631.
Bachet JB, Emile JF, Paye F, Conroy T. European Society of Digestive Oncology guidelines for ampullary carcinoma and periampullary tumors. Ann Surg Oncol. 2020;27(8):2458-2475.
Tanaka S, Kondo S, Hatori T. Clear cell adenocarcinoma of the ampulla of Vater: report of a rare variant. HPB (Oxford). 2018;20(11):1042-1048.
Ohtsuka T, Shimizu H, Miyazaki M. Prognostic factors in ampullary carcinoma and clear cell variants: a systematic review. Br J Surg. 2022;109(6):491-502.
Medication Comparisons
Compare medications used to treat Ampulla Of Vater Clear Cell Adenocarcinoma C1332246. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy