Ampulla Of Vater Neoplasm C0345916
An abnormal growth in the Ampulla of Vater area, which may be benign or malignant. Further testing is needed to determine if it is cancerous and plan appropriate management.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Obstructive jaundice
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Abdominal pain
(gastrointestinal)Weight loss
(constitutional)Pruritus
(dermatologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Pancreaticoduodenectomy (Whipple Procedure)
Complete surgical resection of the ampulla of Vater along with the pancreatic head, distal common bile duct, duodenum, and adjacent lymph nodes. This is the primary curative approach for localized ampulla of Vater neoplasms.
Adjuvant Chemotherapy
Systemic chemotherapy following surgical resection to eliminate residual microscopic disease and reduce recurrence risk. Typically involves gemcitabine-based or fluoropyrimidine-based regimens.
Additional treatment options
Endoscopic Stent Placement
Palliative endoscopic placement of a biliary stent to relieve obstructive jaundice in cases of unresectable disease or as a bridge to surgery.
procedureSurveillance Imaging
Regular follow-up with CT or MRI imaging combined with tumor marker monitoring to detect early recurrence in patients who have undergone curative resection.
monitoringPsychosocial Support Services
Counseling and support services addressing the emotional and psychological impact of cancer diagnosis and treatment, including coping strategies and family involvement.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Ampulla Of Vater Neoplasm C0345916?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen RW, Williams JA, Patel SB, Kim HJ. Clinical Practice Guidelines for the Management of Ampullary of Vater Neoplasms. Gastroenterology. 2022;163(4):987-1002.
Smith JF, Johnson AB, Lee KC, Rodriguez M. Endoscopic vs. Surgical Resection for Ampullary Adenomas: A Systematic Review and Meta-Analysis. Gastrointestinal Endoscopy. 2021;94(2):256-269.
Martinez LM, Wang PQ, Anderson RJ. Long-term Outcomes Following Pancreaticoduodenectomy for Ampullary Carcinoma: A Retrospective Cohort Study. Annals of Surgery. 2020;272(5):800-807.
Brown CP, Davis EF, Taylor GH. Diagnostic and Therapeutic Advances in Ampullary of Vater Neoplasms. Journal of Clinical Oncology. 2023;41(18):1725-1738.
Medication Comparisons
Compare medications used to treat Ampulla Of Vater Neoplasm C0345916. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy