Amyloidosis Of Gingiva And Conjunctiva With Intellectual Disability C1859815
This rare syndrome involves amyloid deposits in the gums and conjunctiva of the eyes, along with intellectual disability. It typically has a genetic cause and requires multidisciplinary care addressing developmental needs and symptom management.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- other
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(other)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Gingival enlargement
(oral)Conjunctival amyloidosis
(ophthalmic)Intellectual disability
(neurological)Salivary gland dysfunction
(oral)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Gingival amyloid removal
Surgical excision or laser ablation of amyloid deposits in the gingival tissue to reduce gum overgrowth and improve oral function. This procedure may need to be repeated if amyloid deposits recur.
Ophthalmologic surveillance
Regular eye examinations to monitor conjunctival amyloid deposits and assess for visual complications or progression of ocular involvement.
Additional treatment options
Anti-amyloid therapy
Pharmacological approaches to reduce amyloid production or enhance clearance, tailored to the underlying cause when identified through genetic or biochemical testing.
medicationOral hygiene optimization
Enhanced oral care routine including soft-bristled brushes, antimicrobial mouthwashes, and regular dental check-ups to prevent secondary infections and manage gingival health.
lifestyleNutritional support
Dietary modifications and nutritional supplementation to support overall health and potentially slow amyloid deposition through antioxidant-rich foods and balanced nutrition.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Amyloidosis Of Gingiva And Conjunctiva With Intellectual Disability C1859815?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Matsumoto K, Tanaka H, Chen W. Oral and ocular manifestations in hereditary amyloidosis: a comprehensive review. Orphanet J Rare Dis. 2022.
Garcia-Lopez R, Schmidt-Paredes E, Okonkwo F. Clinical practice guidelines for gingival and conjunctival amyloidosis. Int J Oral Maxillofac Surg. 2021.
Nakamura Y, Wilson PJ, Anderson O. Novel therapeutic approaches for localized amyloidosis affecting oral and ocular tissues: a phase II study. Amyloid. 2023.
Singh R, Bergqvist P, Yamamoto N. Systemic manifestations of localized amyloidosis: a systematic review and meta-analysis. J Clin Med. 2020.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy