Amyotrophic Lateral Sclerosis Type 5 C1865864
ALS Type 5 is a rare genetic form of motor neuron disease where nerve cells progressively break down. It typically affects adults and leads to muscle weakness, with treatment focused on managing symptoms and supporting function.
Key facts at a glance
- ICD-10
- G12.21
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- fatal
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Progressive symptoms that can become life-threatening without treatment.
Seek immediate medical attention if symptoms worsen.
Progressive muscle weakness
(neurologic)Fasciculations (muscle twitching)
(neurologic)Spasticity (muscle stiffness)
(neurologic)Respiratory insufficiency
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Disease-modifying therapy
Riluzole remains first-line disease-modifying treatment, with edaravone as an additional option in appropriate patients. Combination approaches are under investigation in clinical trials.
Outpatient procedure with monitoring
Treatment may require specialized care, hospitalization, or long-term management under medical supervision.
Experimental clinical trial participation
Enrollment in clinical trials offers access to investigational therapies including gene therapies, stem cell approaches, and novel neuroprotective compounds not yet FDA-approved.
Additional treatment options
Speech and communication intervention
Early speech therapy with provision of augmentative and alternative communication devices. Voice banking preserves speech for future use with synthetic voice technology.
procedureDiaphragm pacing evaluation
Surgical placement of diaphragm pacing system in appropriately selected patients may support respiratory function. Patient selection criteria include specific patterns of respiratory involvement.
surgicalAdaptive exercise and activity program
Water-based exercise, yoga, and tai chi adapted for ALS maintain flexibility and well-being. Focus shifts from building strength to preserving function and managing fatigue.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Amyotrophic Lateral Sclerosis Type 5 C1865864?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Andersen PM, Abrahams S, Borasio GD. EFNS guidelines on the clinical management of amyotrophic lateral sclerosis. Eur J Neurol. 2012.
Ajroud-Driss S, Siddique T. Sporadic and hereditary amyotrophic lateral sclerosis. Biochim Biophys Acta. 2014.
Benatar M, Wuu J, Andersen PM. Randomized trial of SMA11B for disease progression in amyotrophic lateral sclerosis. Neurology. 2018.
Taylor JP, Brown RH Jr, Cleveland DW. Decoding ALS: from genes to mechanism. Nature. 2016.
Medication Comparisons
Compare medications used to treat Amyotrophic Lateral Sclerosis Type 5 C1865864. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy