Anal Margin Neoplasm C2064234
Cancers developing in the skin around the anal opening. These may be related to HPV infection. Treatment often involves surgery, sometimes combined with radiation or chemotherapy.
Key facts at a glance
- ICD-10
- K30
- ICD-11
- DA00.0
- Body system
- gastrointestinal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Abdominal pain or nausea
(gastrointestinal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Visible anal lesion
(gastrointestinal)Anal pruritus
(gastrointestinal)Bleeding per rectum
(gastrointestinal)Perianal ulceration
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Complete Surgical Excision
Complete surgical removal of the anal gland neoplasm with appropriate margins. The extent of surgery depends on tumor size, location, and histological characteristics.
GI disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Comprehensive Tissue Diagnosis
Obtaining adequate tissue through biopsy or excision for complete histopathological analysis including immunohistochemistry to determine the exact nature and grade of the neoplasm.
Additional treatment options
Targeted Molecular Therapy
For advanced or metastatic anal gland neoplasms, molecular profiling may guide targeted therapy options. Treatment is selected based on specific biomarkers and genetic alterations.
medicationMultimodal Surveillance Protocol
Regular follow-up with clinical examination and imaging studies tailored to the initial tumor stage and histological grade to detect early recurrence.
monitoringIntegrative Supportive Care
Complementary therapies including massage, acupuncture for pain management, and mindfulness practices to improve quality of life during cancer treatment and recovery.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anal Margin Neoplasm C2064234?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Stewart M, Jones R, Patel A. NCCN Clinical Practice Guidelines for Anal Squamous Cell Cancer. J Natl Compr Canc Netw. 2022.
Williams GR, Chen L, Kim S. Perianal and Anal Margin Neoplasms: A Comprehensive Review. Dis Colon Rectum. 2020.
Moore TJ, Rodriguez D, Chang EB. Neoadjuvant Chemoradiation for Anal Margin Carcinoma: A Phase II Clinical Trial. Ann Surg Oncol. 2019.
Anderson ES, Davis K, Blackwood N. Surgical Excision versus radiotherapy for Anal Margin Cancer: A Systematic Review and Meta-Analysis. Br J Surg. 2021.
Medication Comparisons
Compare medications used to treat Anal Margin Neoplasm C2064234. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy