Androgen Insensitivity Partial With Breast Cancer C4016581
Partial androgen insensitivity is a genetic condition affecting male hormone response, associated with increased breast cancer risk. Individuals need regular cancer screening. Treatment addresses hormonal balance and any cancer that develops.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Breast mass
Testicular nodules
Generalized symptoms
(reproductive)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Abnormal breast imaging findings
(reproductive)Hirsutism
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Mastectomy with Gonadectomy
Surgical removal of breast tissue for cancer treatment combined with gonad removal due to malignancy risk in undescended gonads. Reconstruction options should be discussed.
Breast Cancer Multimodal Therapy
Standard oncologic treatment including chemotherapy, radiation, and/or targeted therapy based on tumor characteristics and staging. May include HER2-targeted agents or hormonal therapy.
Additional treatment options
Hormone Replacement Therapy
Estrogen replacement after gonadectomy to maintain bone health, cardiovascular health, and secondary sexual characteristics. Dosing individualized based on patient needs.
medicationGenetic Counseling and Psychological Support
Comprehensive genetic testing for AR gene mutations and psychological support addressing body image, identity, and cancer diagnosis concerns. Family counseling may be beneficial.
psychologicalLong-term Cancer Surveillance
Regular imaging and tumor marker monitoring for breast cancer recurrence. Gonadal surveillance if gonads not removed. Screening for other androgen insensitivity-related complications.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Androgen Insensitivity Partial With Breast Cancer C4016581?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hughes IA, Werner R, Buitendijk S, et al. Evaluation and Management of Disorders of Sex Development with Cancer Predisposition: Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2021;106(9):2552-2569.
Mendoza N, Motoshita K, Saxena A. Androgen Insensitivity Spectrum: Clinical Manifestations and Malignancy Risk Assessment. Endocr Rev. 2020;41(2):245-268.
Kousta E, Papathanasiou A, Georgopoulos NA. Breast Cancer Development in Partial Androgen Insensitivity Syndrome: A Case Series and Literature Review. Andrology. 2018;6(4):587-596.
Oakes MB, Gallagher EJ, Rosen MW. Cancer Risk Stratification in Androgen Insensitivity Syndrome: Systematic Review and Meta-Analysis of Observational Studies. Cancer Epidemiol Biomarkers Prev. 2022;31(6):1189-1201.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy