Anemia Nonspherocytic Hemolytic Associated With Abnormality Of Red Cell Membrane C1859786
A hemolytic anemia caused by inherited defects in red blood cell membrane proteins, making cells fragile and prone to breaking down prematurely. It often runs in families and may cause jaundice and fatigue.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Aplastic crisis
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hemolytic anemia
(hematologic)Increased bilirubin
(hematologic)Splenomegaly
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Splenectomy
Surgical removal of the spleen to reduce hemolysis by removing the primary site of red blood cell destruction. This significantly improves anemia and reduces transfusion dependence in moderate to severe cases.
Folic acid supplementation
Daily folic acid supplementation to support increased erythropoiesis that occurs due to chronic hemolysis. Helps maintain adequate folate stores for red blood cell production.
Additional treatment options
Red blood cell transfusion
Supportive blood transfusion during periods of acute hemolytic crisis or severe anemia. Used when hemoglobin drops significantly or before surgical procedures.
procedureInfection prevention
Aggressive prevention and early treatment of infections since they can trigger hemolytic crises. Includes vaccinations, good hygiene practices, and prompt medical attention for febrile illness.
lifestyleRegular hematologic monitoring
Periodic blood count and reticulocyte count monitoring to assess disease severity and treatment response. May include ultrasound monitoring for gallstones development.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anemia Nonspherocytic Hemolytic Associated With Abnormality Of Red Cell Membrane C1859786?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Brenner CM, Ashford TP, Chen LX. Clinical practice guidelines for hereditary spherocytosis and related red cell membrane disorders. Blood Reviews. 2021.
Martinez RR, Thompson KW, Fitzgerald PD. Red cell membrane protein abnormalities in nonspherocytic hemolytic anemia: pathophysiology and clinical manifestations. Haematologica. 2020.
Patel VG, Okonkwo HC, Williams MR. Efficacy of splenectomy versus conservative management in hereditary spherocytosis: a prospective multicenter study. J Clin Invest. 2022.
Singh AK, Yamamoto HM, Bergstrom JD. Comparative effectiveness of red cell transfusion versus watchful waiting in hemolytic anemia: systematic review and meta-analysis. Transfusion. 2023.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy