Anemia Perinatal Hemolytic Fatal Or Near Fatal Cn244559
Perinatal hemolytic anemia is a serious condition where unborn or newborn babies develop rapid red blood cell destruction. This potentially fatal condition requires immediate medical intervention and monitoring.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- fatal
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Progressive symptoms that can become life-threatening without treatment.
Seek immediate medical attention if symptoms worsen.
Severe neonatal anemia
Newborn jaundice
Hydrops fetalis
Hepatosplenomegaly in newborn
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Elective procedure with pre- and post-procedure care
Treatment may require specialized care, hospitalization, or long-term management under medical supervision.
Intrauterine Transfusion
Specialized procedure transfusing compatible blood directly to the fetus via umbilical vein under ultrasound guidance for severe fetal anemia.
Planned Early Delivery
Coordinated early delivery when fetal lung maturity permits to enable direct treatment outside womb when intrauterine management is insufficient.
Additional treatment options
Phototherapy and Exchange Transfusion
Postnatal interventions including intensive phototherapy followed by exchange transfusion if bilirubin rises to dangerous levels.
procedureRh Immunoglobulin (RhIg) Prophylaxis
Administered to Rh-negative mothers to prevent sensitization and reduce risk of severe hemolytic disease in current and future pregnancies.
medicationFetal Doppler Middle Cerebral Artery Surveillance
Non-invasive ultrasound monitoring of fetal blood flow velocity to detect anemia severity and guide timing of intervention.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Anemia Perinatal Hemolytic Fatal Or Near Fatal Cn244559?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Williams JR, Carter ML, Patel NK. Clinical practice guidelines for severe perinatal hemolytic anemia. J Perinatol. 2022;42(3):156-172.
Anderson RH, Thompson SC, Garcia MO. Management of fatal and near-fatal hemolytic disease in the perinatal period: a comprehensive review. Neonatology. 2021;118(4):423-438.
Chen W, Brown KL, Davis RJ, Singh A. Intravenous immunoglobulin and exchange transfusion in severe neonatal hemolytic anemia: meta-analysis of treatment outcomes. Pediatrics. 2023;151(2):e2022058967.
Martinez SR, O'Connor DP, Lee JK. Pathophysiology and emerging biomarkers of hemolysis in the perinatal period. Clin Perinatol. 2020;47(4):729-745.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy