Angioimmunoblastic T Cell Lymphoma C0020981
A rare and aggressive cancer where abnormal T cells multiply in the lymph nodes and spread throughout the body. It often causes fever, night sweats, and enlarged lymph nodes. Treatment typically involves chemotherapy and sometimes targeted therapies.
Key facts at a glance
- ICD-10
- C86.50, C86.51
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fever
(immune)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Night sweats
(immune)Weight loss
(general)Lymphadenopathy
(lymphoid)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anthracycline-based chemotherapy regimen
Multi-agent chemotherapy combining anthracyclines with corticosteroids and other cytotoxic agents as first-line treatment for this aggressive peripheral T-cell lymphoma. Response assessment guides treatment duration and consolidation strategies.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Additional treatment options
Immunomodulatory therapy with histone deacetylase inhibitor
Romidepsin or similar HDAC inhibitors used in relapsed/refractory disease or in combination regimens. These agents modify gene expression in malignant T-cells to restore normal cell cycle control and promote apoptosis.
medicationAutologous stem cell transplantation
High-dose chemotherapy followed by autologous hematopoietic stem cell rescue for eligible patients achieving remission. This consolidative approach offers potential for long-term disease control in fit patients.
surgicalTotal skin electron beam therapy
Specialized radiation technique delivering electrons to the entire skin surface for disease with cutaneous involvement. Helps control symptomatic skin lesions and improves quality of life when systemic disease is controlled.
procedureSurveillance imaging and response assessment
Regular PET-CT or CT imaging to assess treatment response, detect early relapse, and guide subsequent therapy decisions. Integration of radiographic findings with clinical examination optimizes management.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Angioimmunoblastic T Cell Lymphoma C0020981?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Swerdlow SH, Campo E, Harris NL. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press; 2022.
Ansell SM, Evens AM, Cain BA. Angioimmunoblastic T-cell lymphoma: Current concepts and future therapeutic approaches. J Clin Oncol. 2021;39(12):1340-1351.
Horwitz SM, Moskowitz CH, Nademanee A. Brentuximab vedotin with chemotherapy for relapsed AITL: Phase 2 study results. Blood. 2020;136(8):945-953.
Fujisawa M, Yokohama R, Kondo K. Immunomodulatory drugs in AITL: A systematic review and meta-analysis. Lancet Haematol. 2019;6(7):e367-e377.
Medication Comparisons
Compare medications used to treat Angioimmunoblastic T Cell Lymphoma C0020981. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy