Ano5 Related Muscle Disease Cn381199
A muscle disease caused by ANO5 gene mutations, leading to progressive weakness primarily in the limbs and hips. It typically develops in adulthood and is managed with physical therapy and supportive care.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Respiratory muscle weakness
Exercise intolerance
(musculoskeletal)Joint pain or stiffness
(musculoskeletal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Difficulty rising from a chair
(musculoskeletal)Muscle cramps
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aquatic therapy and low-impact exercises
Water-based exercises reduce joint stress while allowing muscle strengthening. Includes swimming, water walking, and resistance training in pool.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Multidisciplinary disease surveillance
Coordinated care involving neurology, cardiology, and pulmonology with regular testing to detect muscle, cardiac, or respiratory complications early.
Additional treatment options
Muscle cramp and spasm management
Use of muscle relaxants, anti-convulsants for neuropathic pain, or other agents as prescribed for management of painful muscle symptoms.
medicationHome exercise and self-management program
Structured home-based exercise routine with regular reassessment to maintain muscle strength, flexibility, and functional independence between therapy sessions.
lifestylePhysical and occupational therapy consultation
Comprehensive evaluation and intervention for activities of daily living, functional mobility, and use of adaptive equipment.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Ano5 Related Muscle Disease Cn381199?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schneider I, Wahba K, Deschauer M. ANO5-Related Muscular Dystrophy: Current Understanding and Future Perspectives. Neuromuscular Disorders. 2020.
European Neuromuscular Centre Guidelines Committee. Consensus Guidelines for the Diagnosis and Management of ANO5-Related Muscle Disease. Muscle Nerve. 2022.
Penttilä S, Palmio J, Udd B. Clinical Phenotype and Natural History of ANO5-Related Myopathy: A Prospective Cohort Study. Journal of Neurology. 2021.
Bhatia R, Dayanandan R, Bhatt JM. Novel ANO5 Gene Mutations in Indian Patients with Limb-Girdle Muscular Dystrophy. Indian Journal of Medical Research. 2023.
Medication Comparisons
Compare medications used to treat Ano5 Related Muscle Disease Cn381199. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy