Anti Basement Membrane Glomerulonephritis C1332309
An autoimmune condition where antibodies attack the kidney's filtering structures, causing inflammation and rapid loss of kidney function. Also known as Goodpasture syndrome when it affects both kidneys and lungs. Urgent treatment with immunosuppression and plasma exchange is often necessary.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hemoptysis
Dyspnea
Acute kidney injury
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Hematuria
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Therapeutic plasmapheresis
Removes circulating anti-GBM antibodies and inflammatory mediators from plasma, critical for preventing further kidney and lung damage.
High-dose corticosteroids with cyclophosphamide
Aggressive immunosuppression to halt antibody production and inflammation in kidney glomeruli and pulmonary alveoli.
Additional treatment options
Renal replacement therapy
Dialysis support for patients with end-stage renal disease from severe glomerulonephritis while awaiting potential kidney recovery or transplant.
surgicalKidney-friendly dietary modifications
Sodium restriction, protein moderation, and potassium/phosphorus management to reduce kidney burden and manage complications.
dietaryFrequent renal function and antibody monitoring
Serial creatinine, eGFR, and anti-GBM antibody titers to assess treatment response and detect early relapse.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Basement Membrane Glomerulonephritis C1332309?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
KDIGO. KDIGO Clinical Practice Guideline for Glomerulonephritis. Kidney Int Suppl. 2021;11(2):1-274.
McAdoo SP, Pusey CD. Anti-glomerular basement membrane disease. Clin J Am Soc Nephrol. 2017;12(11):1682-1693.
Liu J, Wang Y, Chen L, et al. Treatment outcomes in anti-GBM disease: a systematic review and meta-analysis. Nephrol Dial Transplant. 2020;35(10):1740-1750.
Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG. Alport's syndrome, Goodpasture's syndrome, and type IV collagen. N Engl J Med. 2003;348(25):2543-2556.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy