Anti Caspr2 C5558404
Anti-Caspr2 antibodies target nerve proteins and can cause Morvan syndrome or limbic encephalitis, leading to muscle twitching, autonomic problems, and sleep disturbances.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Limbic encephalitis
Seizures
Neuromyotonia
Morvan syndrome
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Therapeutic Plasma Exchange
Plasmapheresis removes pathogenic antibodies from circulation, reducing antibody-mediated neuronal damage. Typically performed as series of exchanges over 2-4 weeks.
Intravenous Immunoglobulin
IVIG modulates immune function and blocks antibody-mediated toxicity through Fc receptor saturation. Dosed based on weight with gradual infusion.
Additional treatment options
Rituximab
Monoclonal antibody targeting CD20 depletes B-cells, reducing autoantibody production. Reserved for refractory cases or as steroid-sparing agent.
medicationCorticosteroid Therapy
High-dose corticosteroids suppress overall immune response and reduce inflammation at neural sites. Tapering schedule prevents adrenal insufficiency.
medicationNeuroimmunology Follow-up
Regular neurological assessment and antibody titer monitoring to evaluate treatment response and detect relapse early.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Caspr2 C5558404?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Vincent A, Irani SR, Lang B. Caspr2 antibodies in autoimmune encephalitis and related disorders. Neurology. 2020.
Graus F, Titulaer MJ, Balu R, et al. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurology. 2021.
Irani SR, Pettingill P, Kleopa KA, et al. Morvan syndrome associated with Caspr2 antibodies. JAMA Neurology. 2018.
Dalmau J, Geis C, Graus F. Autoantibodies to synaptic receptors and neuronal cell surface proteins in autoimmune encephalitis. Physiological Reviews. 2019.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy