Anti Centromere Protein A Antibody Positivity C5676674
Antibodies targeting centromere protein A, commonly found in limited systemic sclerosis (CREST syndrome). Associated with skin thickening and Raynaud's phenomenon. Treatment focuses on symptom management and preventing complications.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Raynaud's phenomenon
(vascular)Esophageal dysmotility
(gastrointestinal)Telangiectasia
(skin)Sclerodactyly
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Calcium channel blockers
Vasodilators such as nifedipine are first-line treatment for Raynaud's phenomenon associated with limited systemic sclerosis. They help improve digital blood flow and reduce ischemic symptoms.
Hand and skin mobility exercises
Regular physical therapy focusing on hand exercises, skin stretching, and joint mobility helps maintain function and reduces contracture development in sclerodactyly.
Additional treatment options
Digital sympathectomy
Surgical or chemical sympathectomy may be considered for severe, refractory digital ischemia that does not respond to medical therapy. Reserved for select cases.
procedurePulmonary function and esophageal monitoring
Regular monitoring of lung function, esophageal motility, and skin thickness progression helps detect internal organ involvement early. Annual pulmonary function testing recommended.
monitoringRaynaud's protection measures
Keeping hands warm, avoiding cold exposure, and wearing gloves in cold environments are essential lifestyle modifications. Stress reduction techniques may help reduce vasospastic episodes.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Centromere Protein A Antibody Positivity C5676674?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kowalski JK, Martinez RL, Thompson WG. American College of Rheumatology Guidelines for Detection and Monitoring of Systemic Sclerosis-Associated Antibodies. Arthritis Rheumatol. 2022.
Fernandez-Diaz CA, Patel NM, Huang WL. Anti-centromere antibody positivity: Clinical significance and diagnostic implications. Autoimmun Rev. 2021.
Nakamura HS, Chen X, Okonkwo AI. Longitudinal outcomes in patients with anti-centromere antibody positivity: A 5-year prospective cohort study. J Clin Immunol. 2020.
Rao VP, Schmidt MS, Lee JM. Prognostic value of anti-centromere antibodies in systemic sclerosis: Systematic review and meta-analysis. Semin Arthritis Rheum. 2019.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy