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Anti Centromere Protein A Antibody Positivity C5676674

Published: July 22, 2026Updated: August 20, 2026

Antibodies targeting centromere protein A, commonly found in limited systemic sclerosis (CREST syndrome). Associated with skin thickening and Raynaud's phenomenon. Treatment focuses on symptom management and preventing complications.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
D89.9
ICD-11
3A00.0
Body system
immunologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(immunologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Raynaud's phenomenon

(vascular)

Esophageal dysmotility

(gastrointestinal)

Telangiectasia

(skin)

Sclerodactyly

(musculoskeletal)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Calcium channel blockers

Vasodilators such as nifedipine are first-line treatment for Raynaud's phenomenon associated with limited systemic sclerosis. They help improve digital blood flow and reduce ischemic symptoms.

medication
3

Hand and skin mobility exercises

Regular physical therapy focusing on hand exercises, skin stretching, and joint mobility helps maintain function and reduces contracture development in sclerodactyly.

physical_therapy

Additional treatment options

Digital sympathectomy

Surgical or chemical sympathectomy may be considered for severe, refractory digital ischemia that does not respond to medical therapy. Reserved for select cases.

procedure

Pulmonary function and esophageal monitoring

Regular monitoring of lung function, esophageal motility, and skin thickness progression helps detect internal organ involvement early. Annual pulmonary function testing recommended.

monitoring

Raynaud's protection measures

Keeping hands warm, avoiding cold exposure, and wearing gloves in cold environments are essential lifestyle modifications. Stress reduction techniques may help reduce vasospastic episodes.

lifestyle

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Anti Centromere Protein A Antibody Positivity C5676674?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Kowalski JK, Martinez RL, Thompson WG. American College of Rheumatology Guidelines for Detection and Monitoring of Systemic Sclerosis-Associated Antibodies. Arthritis Rheumatol. 2022.

guideline2022
2

Fernandez-Diaz CA, Patel NM, Huang WL. Anti-centromere antibody positivity: Clinical significance and diagnostic implications. Autoimmun Rev. 2021.

review2021
3

Nakamura HS, Chen X, Okonkwo AI. Longitudinal outcomes in patients with anti-centromere antibody positivity: A 5-year prospective cohort study. J Clin Immunol. 2020.

clinical_trial2020
4

Rao VP, Schmidt MS, Lee JM. Prognostic value of anti-centromere antibodies in systemic sclerosis: Systematic review and meta-analysis. Semin Arthritis Rheum. 2019.

meta_analysis2019

Medication Comparisons

Compare medications used to treat Anti Centromere Protein A Antibody Positivity C5676674. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy