Anti Class I Hla Antibody Positivity C5558386
Presence of antibodies targeting Class I HLA proteins on cells. Seen in transplant recipients and can lead to rejection of donor tissue.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Kidney transplant graft dysfunction
Acute rejection episode
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypertension
(cardiovascular)Proteinuria
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunosuppressive therapy
Agents such as mycophenolate mofetil or azathioprine may be used to reduce HLA antibody levels, particularly in transplant recipients or those with antibody-mediated conditions.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Serial antibody monitoring
Regular assessment of HLA antibody levels helps guide treatment decisions and predict outcomes. Frequency depends on clinical context and recent interventions.
Additional treatment options
Plasmapheresis
Therapeutic plasma exchange can remove pathogenic antibodies from circulation. Often used in acute antibody-mediated rejection or severe autoimmune conditions.
procedureB-cell targeted therapy
Rituximab or other biologic agents targeting B-cells may be used to reduce antibody production. Reserved for refractory cases or specific clinical scenarios.
medicationHigh-dose intravenous immunoglobulin
IVIG therapy modulates immune function and may help reduce antibody-mediated damage. Used in various antibody-positive conditions and transplant rejection.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Class I Hla Antibody Positivity C5558386?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Tait BD, Süsal C, Gebel HM, et al. Consensus Guidelines on the Testing and Clinical Management Issues Associated with HLA and Non-HLA Antibodies in Transplantation. Transplantation. 2018.
Zachary AA, Kopchaliiska D, Jackson AM, Leffell MS. Immunologic Considerations for Highly Sensitized Patients Awaiting Renal Transplantation. Immunol Invest. 2019.
Amrouche L, Aubert O, Suberbielle C, et al. Efficacy of Bortezomib-Based Desensitization Protocols in Kidney Transplant Recipients with Donor-Specific Antibodies. Am J Transplant. 2020.
Kang J, Kim HS, Kim JY, Lee SH. Impact of Preformed Anti-HLA Class I Antibodies on Renal Allograft Outcomes: A Systematic Review and Meta-Analysis. Clin J Am Soc Nephrol. 2021.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy