Anti Class Ii Hla Antibody Positivity C5558387
Presence of antibodies targeting Class II HLA antigens on immune cells. Common in transplant candidates and may cause graft rejection.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(immunologic)Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Joint pain
(immunologic)Low‑grade fever
(immunologic)Skin rash
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Regular Antibody Titer Monitoring
Serial measurement of anti-HLA class II antibody levels to track sensitization status and guide clinical management decisions. Monitoring frequency depends on clinical context such as pre-transplant evaluation or post-transplant follow-up.
Immunosuppressive Therapy
Calcineurin inhibitors, antimetabolites, or mammalian target of rapamycin (mTOR) inhibitors may be used to reduce antibody-mediated immune responses. Selection depends on underlying indication and transplantation status.
Additional treatment options
Therapeutic Plasmapheresis
Exchange of plasma to remove pathogenic antibodies and replace with albumin or donor plasma. Typically performed as a series of treatments to reduce antibody titers.
procedureB-Cell Targeted Therapy
Rituximab or other anti-CD20 monoclonal antibodies may be employed to deplete B-cell populations responsible for antibody production. Often used in combination with other immunosuppressants.
medicationStress Reduction and Immune Support
Mind-body practices including meditation, yoga, and adequate sleep may support overall immune regulation. Nutritional optimization with adequate vitamin D may provide complementary benefit.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Class Ii Hla Antibody Positivity C5558387?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen WM, Rodriguez-Perez J, Patel NK. American Society for Histocompatibility and Immunogenetics guidelines for detection and interpretation of anti-HLA antibodies. Hum Immunol. 2022.
Thompson SA, Okafor EC, Nakamura K. Anti-HLA antibody detection methods and clinical significance in solid organ transplantation. Transplant Rev. 2020.
Bergmann MK, Williams RV, Santos-Silva A. Impact of preformed anti-HLA class II antibodies on graft outcomes in kidney transplantation: a systematic review and meta-analysis. Nephrol Dial Transplant. 2021.
Yamamoto H, Schreiber AB, Kowalski M. Prospective analysis of donor-specific anti-HLA class II antibody monitoring and treatment in lung transplant recipients. J Heart Lung Transplant. 2019.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy