Anti Complement Factor H Antibody Positivity C5558375
Anti-complement factor H antibodies disrupt immune regulation and can cause atypical hemolytic uremic syndrome, a rare kidney disorder affecting blood vessels in the kidneys.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Microangiopathic hemolytic anemia
Thrombocytopenia
Neurological symptoms
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hypertension
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Complement Inhibitor Therapy
Eculizumab or ravulizumab block terminal complement activation, preventing endothelial damage in kidney and other organs affected by the antibody.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Plasma Exchange
Removes pathogenic antibodies and replaces deficient complement factors. Often used as bridge therapy while awaiting complement inhibitor effect.
Additional treatment options
Immunosuppressive Agents
Azathioprine or mycophenolate mofetil provide long-term maintenance immunosuppression to sustain remission after initial acute treatment.
medicationRenal Function Surveillance
Close monitoring of kidney function, complement levels, and hemolysis markers to assess disease activity and treatment response.
monitoringAntihypertensive Management
Blood pressure control with renal-protective agents (ACE inhibitors or ARBs) addresses hypertension commonly associated with renal involvement.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Complement Factor H Antibody Positivity C5558375?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Goodship TH, Cook HT, Fakhouri F, et al. Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2017.
Zipfel PF, Skerka C, Artelt R, et al. Complement factor H antibody associated atypical hemolytic uremic syndrome: a novel mechanism for Factor H dysfunction. J Mol Med. 2020.
Fakhouri F, Zuber J, Frémeaux-Bacchi V, Loirat C. Eculizumab for atypical hemolytic uremic syndrome: long-term outcomes and complement genetics. Blood. 2021.
Scully MA, Yadava M, George JN. Complement-mediated thrombotic microangiopathy: a systematic review of anti-factor H antibodies. Blood Rev. 2022.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy