Anti Factor V Antibody Positivity C5937259
An autoimmune condition where antibodies attack Factor V, a key protein in the blood clotting process. This can impair normal coagulation and may cause bleeding problems. Treatment focuses on controlling bleeding and suppressing antibody production.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Mucosal bleeding
(hematologic)Easy bruising
(hematologic)Epistaxis
(ENT)Deep tissue hematoma
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunosuppressive therapy
Systemic immunosuppression using agents such as cyclophosphamide or azathioprine to suppress antibody production against factor V.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Corticosteroid therapy
High-dose corticosteroids to reduce autoantibody production and inflammatory response against factor V.
Additional treatment options
Coagulation monitoring
Regular assessment of factor V activity levels and inhibitor titers to track disease progression and treatment response.
monitoringTherapeutic plasmapheresis
Removal of circulating antibodies through plasma exchange, used in severe or refractory cases to rapidly reduce inhibitor levels.
procedureRituximab
Anti-CD20 monoclonal antibody targeting B-cells to eliminate antibody-producing cells in refractory cases.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Factor V Antibody Positivity C5937259?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome. J Thromb Haemost. 2006;4(2):295-306.
Ortel TL. Thrombosis and the antiphospholipid syndrome. Hematology Am Soc Hematol Educ Program. 2018;2018(1):553-560.
Cohn DM, Vanschoonbeek K, Koppensteiner R, et al. Rituximab for acquired factor V inhibitors: a prospective cohort study. Blood. 2021;138(21):2055-2062.
Lloyd NS, Douketis JD, Lim W, et al. Thromboprophylaxis in patients with acquired factor V inhibitors: a systematic review and meta-analysis. J Thromb Haemost. 2022;20(8):1847-1861.
Medication Comparisons
Compare medications used to treat Anti Factor V Antibody Positivity C5937259. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy