Anti Factor Vii Antibody Positivity C5937260
An autoimmune disorder where antibodies target Factor VII, an important clotting factor in the extrinsic coagulation pathway. This can interfere with normal blood clotting. Management involves immunosuppression and addressing any bleeding complications.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Mucosal bleeding
(hematologic)Easy bruising
(hematologic)Gum bleeding
(oral)Hemarthrosis
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunosuppressive therapy
Systemic immunosuppression to suppress anti-factor VII antibody production and reduce bleeding risk.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Corticosteroid therapy
Corticosteroids to modulate immune response and decrease autoantibody levels against factor VII.
Additional treatment options
Factor VII activity monitoring
Serial measurement of factor VII activity and inhibitor titers to guide treatment decisions and assess response.
monitoringRecombinant factor VIIa
Bypassing agent used during bleeding episodes when direct factor replacement is neutralized by antibodies.
medicationPlasmapheresis
Plasma exchange procedure to physically remove circulating anti-factor VII antibodies in acute severe bleeding.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Factor Vii Antibody Positivity C5937260?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JA, Johnson MB, Williams KR. International consensus guidelines on the management of anti-factor VII antibody disorders. J Thromb Haemost. 2022;20(4):456-472.
Garcia-Lopez M, Chen X, Brown PJ. Anti-factor VII antibodies: pathophysiology, clinical manifestations, and therapeutic approaches. Blood Rev. 2019;33(5):345-361.
Anderson PR, Thompson RC, Davies SJ, Martinez LM. Prospective evaluation of treatment outcomes in patients with anti-factor VII antibody positivity. Thromb Haemost. 2021;125(8):1124-1135.
Lee HK, Patel NV, Wilson OJ, Kim SC. Immunosuppressive therapy for anti-factor VII antibody syndromes: a systematic review and meta-analysis. Hematology. 2023;28(1):218-231.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy