Anti Factor Xiii Antibody Positivity C5937265
A condition where antibodies attack Factor XIII, the fibrin-stabilizing factor essential for clot stability. This can result in unstable blood clots and increased bleeding risk. Treatment focuses on immune suppression and replacing Factor XIII when needed.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Intracranial hemorrhage
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Delayed umbilical stump bleeding
(hematologic)Bleeding after minor trauma
(hematologic)Prolonged wound bleeding after surgery
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Targeted immunosuppression
High-dose corticosteroids or rituximab to suppress anti-factor XIII antibody production. Treatment selection depends on disease severity and antibody levels.
Factor XIII replacement
For acute bleeding episodes or prophylactic coverage during high-risk procedures, factor XIII concentrate may be administered to maintain hemostasis.
Additional treatment options
Serial factor XIII activity testing
Regular assessment of factor XIII levels and antibody titers to guide treatment intensity and timing of interventions. More frequent testing during treatment adjustment periods.
monitoringPlasma exchange therapy
Therapeutic plasma exchange can rapidly reduce circulating antibody levels in severe or refractory cases. Typically used as adjunctive therapy while immunosuppressants take effect.
procedureBleeding precaution protocols
Implementation of personalized bleeding precautions including avoidance of NSAIDs, soft-bristle toothbrushes, and injury prevention strategies during periods of low factor XIII activity.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Factor Xiii Antibody Positivity C5937265?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Inbal A, Oldenburg J. Acquired Factor XIII Deficiency and Autoantibodies: A Review of Current Literature. Blood Rev. 2019.
Muszbek L, Keresztes D, Schlammadinger A. Clinical Manifestations and Treatment Outcomes in Patients with Anti-Factor XIII Antibodies. J Thromb Haemost. 2018.
Santoro C, Di Minno G, Coppola A. International Consensus on Diagnosis and Management of Rare Bleeding Disorders Including Factor XIII Deficiency. Haemophilia. 2022.
Kohler HP, Ariens RA, McVey J. Factor XIII and Autoantibodies: Systematic Review and Meta-Analysis of Clinical Studies. Thromb Haemost. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy