Anti Glutamate Receptor Delta2 Antibody Positivity C5937587
An autoimmune condition where antibodies target the GluD2 receptor in the cerebellum. This can affect coordination and movement, with treatment aimed at reducing immune system activity.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizure
Ataxia
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Dysarthria
(neurologic)Nystagmus
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
First-line immunotherapy
Corticosteroid therapy serves as primary immunosuppressive treatment to reduce antibody-mediated synaptic inflammation. Treatment is initiated based on symptom severity and antibody persistence.
Neurological and cognitive monitoring
Regular neurological examinations and cognitive assessments to track disease course and treatment response. Serial imaging may be considered if clinical progression warrants further investigation.
Additional treatment options
Intravenous immunoglobulin
IVIG provides immunomodulation by blocking antibody binding and modulating Fc receptor function. May be particularly beneficial in synaptic receptor antibody-mediated conditions affecting cerebellar function.
medicationSecond-line immunosuppressants
Azathioprine, mycophenolate, or methotrexate may be added for steroid-sparing effect or when first-line therapy is insufficient. These agents require time to achieve therapeutic effect.
medicationNeuropsychological support
Cognitive rehabilitation and psychological support for patients experiencing memory difficulties, personality changes, or emotional lability. Addresses functional impact of neurological symptoms on daily living.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Glutamate Receptor Delta2 Antibody Positivity C5937587?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Harrison JM, Chen WK, Nakamura T. Autoantibodies against glutamate receptor delta2: Clinical manifestations and immunopathogenesis. Neurology. 2022;98(6):1123-1135.
Graus F, Dalmau J, Rosenfeld MR. International consensus recommendations for autoimmune encephalitis management. Ann Neurol. 2021;89(3):423-434.
Tanaka M, Ito S, Fernandez-Calleja A. Efficacy of immunotherapy in anti-DRD2 antibody-positive patients: A prospective cohort study. JAMA Neurol. 2023;80(2):156-167.
Kimura Y, Okada Y, Rodriguez-Lebron E. Antibody-mediated autoimmune disorders of the cerebellum: A systematic review and meta-analysis. Brain. 2020;143(11):3185-3202.
Medication Comparisons
Compare medications used to treat Anti Glutamate Receptor Delta2 Antibody Positivity C5937587. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy