Anti Hexokinase 1 Antibody Positivity C5676710
Autoantibodies targeting hexokinase 1, an enzyme involved in glucose metabolism. May occur with certain cancers or autoimmune conditions. Monitoring and further evaluation recommended.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(general)Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Arthralgia
(musculoskeletal)Myalgia
(musculoskeletal)Raynaud's phenomenon
(vascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive endocrine monitoring
Regular assessment of multiple endocrine organs, autoantibody levels, and organ function to detect and manage autoimmune polyendocrine involvement.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Organ-specific hormone replacement
Replacement of deficient hormones such as adrenal steroids, thyroid hormones, or sex hormones based on documented deficiencies.
Additional treatment options
Immunosuppressive therapy
Immunomodulatory medications including corticosteroids and other agents to control autoimmune hepatitis and other inflammatory manifestations.
medicationNutritional supplementation program
Targeted supplementation addressing specific deficiencies commonly seen in this condition, including vitamin D, B12, and mineral repletion.
dietarySpecialist-directed diagnostic procedures
Periodic procedures such as liver biopsy, imaging studies, or endocrine function tests as indicated by clinical findings.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Hexokinase 1 Antibody Positivity C5676710?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krishnamurthy A, Chen W, Nunez J. Autoantibodies Targeting Metabolic Enzymes in Autoimmune Disorders: Focus on Hexokinase 1. Autoimmun Rev. 2022.
Williams R, Thompson K, Patel M, Garcia S. International Consensus Guidelines for Detection and Management of Autoimmune Encephalopathies. Neurology. 2021.
Martinez-Lopez J, Anderson EC, Yamamoto H. Clinical Features and Outcomes of Anti-Hexokinase 1 Antibody Positive Patients: A Prospective Cohort Study. J Clin Immunol. 2023.
Brownlee J, Fischer T, Davies L. Diagnostic Accuracy of Neuronal Autoantibody Testing Panels: A Systematic Review and Meta-Analysis. Ann Neurol. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy