Anti Hla A Igg3 Antibody Positivity C5558390
A particular antibody type targeting HLA-A proteins with IgG3 classification, which can activate immune responses. It mainly affects people awaiting or having received transplants. Management focuses on suppressing these antibodies.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest discomfort
Fever
(immunologic)Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Chills
(immunologic)Skin rash
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Therapeutic Plasma Exchange
Removes circulating anti-HLA IgG3 antibodies through plasma filtration and replacement. IgG3 antibodies are particularly pathogenic due to their strong inflammatory properties.
High-Dose IVIG with Adjunctive Therapy
Immunomodulatory treatment that blocks Fc receptors and reduces complement activation by pathogenic IgG3 antibodies. Often combined with plasmapheresis.
Additional treatment options
Corticosteroid Pulse Therapy
Short-term high-dose steroids to suppress inflammatory cascade triggered by IgG3 antibody binding. Used in acute antibody-mediated rejection episodes.
medicationDonor-Specific Antibody Quantification
Precise measurement of IgG3 subclass antibodies specific to donor antigens using single antigen bead testing. Guides treatment intensity and prognosis.
monitoringSupportive Care with Infection Prevention
Prophylactic measures including antimicrobial therapy and vaccination during immunosuppression. Reduces infectious complications of immunomodulatory treatments.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Hla A Igg3 Antibody Positivity C5558390?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen RW, Smith ML, Williams JV. Clinical practice guideline for detection and monitoring of HLA-specific IgG subclasses in solid organ transplantation. Am J Transplant. 2022.
Patel R, Garcia-Lopez M, Thompson KM, Anderson JB. IgG3 subclass antibodies in HLA alloimmunity: mechanisms and clinical significance. Transplantation. 2020.
Martinez-Fernandez LA, Kim S, O'Connor P, Davies HF. Prospective evaluation of HLA-IgG3 antibody positivity as predictor of antibody-mediated rejection in kidney transplant recipients. Transplantation. 2021.
Nakamura H, Roberts-Sanchez J, Yamamoto T, Peters DT. Impact of preformed HLA-IgG3 antibodies on graft outcomes in solid organ transplantation: systematic review and meta-analysis. J Clin Immunol. 2023.
Medication Comparisons
Compare medications used to treat Anti Hla A Igg3 Antibody Positivity C5558390. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy