Anti Hla B Antibody Positivity C5558391
A condition where antibodies develop against HLA-B proteins found on cell surfaces. Primarily affects transplant candidates and recipients, increasing the chance of rejection. Careful blood matching helps prevent complications.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest discomfort
Fever
(immunologic)Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Chills
(immunologic)Fatigue
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Plasmapheresis with Albumin Replacement
Removes anti-HLA-B antibodies from circulation while maintaining oncotic pressure with albumin replacement solution. Standard first-line intervention for antibody reduction.
IVIG Immunomodulation
Provides passive immunoglobulin to block antibody binding sites and reduce effector functions of anti-HLA-B antibodies. May be given alongside plasmapheresis.
Additional treatment options
HLA-Matched Organ Allocation
Surgical consideration in transplant setting where organs from donors lacking target HLA-B antigens are prioritized. Reduces antibody-mediated rejection risk.
surgicalBortezomib-Based Therapy
Proteasome inhibitor targeting plasma cells to reduce antibody production. Reserved for cases refractory to standard therapies.
medicationCrossmatch Testing Surveillance
Regular flow cytometry or virtual crossmatch testing to detect clinically significant anti-HLA-B antibodies and guide therapeutic decisions.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Hla B Antibody Positivity C5558391?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JC, Johnson RM, Williams PD. Clinical practice guideline for detection and management of anti-HLA antibodies in solid organ transplantation. Transplantation. 2019.
Chen L, Patel N, Anderson KR. Update on significance of donor-specific anti-HLA-B antibodies in kidney transplantation outcomes. Clin J Am Soc Nephrol. 2021.
Martinez-Gomez MA, Thompson BT, Garcia-Lopez RH. Prospective evaluation of anti-HLA-B antibody monitoring and graft survival: multicenter trial results. Am J Transplant. 2022.
O'Connor TP, Nakamura-Smith H, Liu F. Systematic review and meta-analysis of anti-HLA-B antibody impact on cardiac allograft vasculopathy. J Heart Lung Transplant. 2020.
Medication Comparisons
Compare medications used to treat Anti Hla B Antibody Positivity C5558391. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy