Anti Kelch Like Protein 12 Antibody Positivity C5676711
Presence of antibodies against KLHL12 protein. A relatively newly identified antibody marker that may be associated with certain autoimmune disorders.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Swelling of joints
(immunologic)Nausea
(immunologic)Malaise
(immunologic)Lymphadenopathy
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Corticosteroid therapy
First-line treatment with corticosteroids to suppress hepatic inflammation and prevent progression of autoimmune liver disease associated with anti-kelch-like protein 12 antibodies.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Steroid-sparing immunosuppressants
Second-line agents such as azathioprine may be added for long-term maintenance and steroid dose reduction in chronic cases.
Additional treatment options
Hepatic function surveillance
Frequent monitoring of liver enzymes, bilirubin, and hepatic function tests to assess disease activity and treatment response.
monitoringHepatic-friendly nutrition
Low-sodium, moderate protein diet with avoidance of alcohol and hepatotoxic substances supports liver function during treatment.
dietaryLiver biopsy for staging
Periodic liver biopsy may be performed to assess histological response to treatment and disease stage.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Kelch Like Protein 12 Antibody Positivity C5676711?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen R, Patel S, Yamamoto K. Autoimmune disorders associated with anti-cytoskeletal protein antibodies: focus on anti-KLHL12 antibody positivity. Autoimmun Rev. 2021.
International Consortium for Autoimmune Neurology, Nakamura T, Bergler M, et al. Consensus guidelines for the management of autoimmune encephalopathies with anti-cytoskeletal antibodies. Neurology. 2022.
Liu H, Johansson J, Kimura N, Webb P. Clinical features and treatment outcomes in patients with anti-KLHL12 antibody positivity: a prospective cohort study. J Neuroimmunol. 2020.
Tanaka M, Okonkwo C, Schmidt H, Dubois A. Characterization of anti-Kelch-like protein 12 antibodies in patients with peripheral neuropathy: a case series. Muscle Nerve. 2019.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy