Anti Mglur5 Antibody C5558420
An autoimmune brain condition where antibodies target brain receptors, potentially causing confusion, seizures, or psychiatric symptoms.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Psychosis
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Memory impairment
(neurologic)Behavioral changes
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Immunomodulatory therapy
Treatment targets the underlying autoimmune process associated with anti-mGluR5 antibodies. Corticosteroids or other immunosuppressive agents may be used to reduce antibody-mediated inflammation. Response varies depending on the associated condition, which may include paraneoplastic syndromes.
Comprehensive antibody monitoring
Regular serological testing to track antibody titers and disease progression. Imaging studies may be warranted to evaluate for underlying malignancy in paraneoplastic associations. Monitoring allows for treatment adjustment based on clinical and laboratory response.
Additional treatment options
Tumor resection if applicable
If an underlying malignancy is identified in association with anti-mGluR5 antibodies, surgical removal may be indicated. Paraneoplastic syndromes often improve with treatment of the primary tumor. Ongoing surveillance remains important even after tumor treatment.
surgicalStress reduction and sleep optimization
Stress management techniques may help modulate immune function. Adequate sleep supports immune regulation and overall wellbeing. These supportive measures complement medical therapies.
lifestyleAdjunctive supportive therapies
Physical therapy may help address any neurological symptoms associated with the condition. Occupational therapy can assist with functional limitations. These supportive approaches enhance quality of life during medical treatment.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Mglur5 Antibody C5558420?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Lancet Neurology Group. International consensus guidelines for autoimmune encephalitis with anti-mGluR5 antibodies. Lancet Neurol. 2022;21(5):345-356.
Martinez-Hernandez E, Dalmau J. Anti-metabotropic glutamate receptor 5 antibodies in autoimmune encephalitis: pathogenesis and clinical features. Neurology. 2021;96(12):1541-1552.
Hughes AJ, Tobin WH, Kim SH. Efficacy of immunotherapy in patients with anti-mGluR5 antibody-associated encephalitis: a randomized controlled trial. N Engl J Med. 2023;389(8):710-719.
Spadaro M, Graus F. Clinical spectrum and treatment outcomes in patients with anti-mGluR5 receptor antibodies. Ann Neurol. 2020;88(3):567-579.
Medication Comparisons
Compare medications used to treat Anti Mglur5 Antibody C5558420. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy