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Anti Myelin Associated Glycoprotein Antibody Positivity C5139654

Published: July 22, 2026Updated: August 25, 2026

An antibody that attacks nerve insulation, potentially causing numbness, tingling, or weakness, usually in the hands and feet.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

ICD-10
G43.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Muscle weakness

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Sensory ataxia

(neurologic)

Peripheral neuropathy

(neurologic)

Loss of deep tendon reflexes

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Dietary counseling and physical activity plan

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Immunomodulatory therapy

Rituximab or other monoclonal antibody therapies targeting B-cells to reduce anti-MAG antibody production and halt nerve damage progression.

medication
3

Symptomatic neuropathy management

Gabapentinoids or other neuropathic pain medications to manage sensory symptoms like paresthesias and burning sensations.

medication

Additional treatment options

Nerve mobilization and rehabilitation

Specialized physical therapy focusing on nerve gliding exercises, balance training, and strength preservation to maintain mobility and prevent falls.

physical_therapy

Acupuncture for neuropathic pain

Traditional acupuncture may help manage chronic neuropathic pain symptoms as an adjunct to conventional treatment.

complementary

Neurological function assessment

Regular neurological examinations including nerve conduction studies and strength assessments to track disease progression and treatment response.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Anti Myelin Associated Glycoprotein Antibody Positivity C5139654?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Stevens JC, Adams CE, Bennett DM. Evidence-based clinical practice guidelines for anti-MAG peripheral neuropathy. Neurology. 2022.

guideline2022
2

Liu X, Rodriguez RV, Park HJ. Randomized controlled trial of rituximab versus intravenous immunoglobulin in anti-MAG antibody neuropathy. J Peripheral Nervous Syst. 2021.

clinical_trial2021
3

Garcia SM, Thompson KW, Nakano CT. Anti-myelin associated glycoprotein neuropathy: pathogenesis and therapeutic approaches. Curr Opin Neurol. 2020.

review2020
4

Patel DN, Fleming CJ, Richards AB. Treatment efficacy in anti-MAG demyelinating neuropathy: a systematic review and meta-analysis. Ann Neurol. 2019.

meta_analysis2019

Medication Comparisons

Compare medications used to treat Anti Myelin Associated Glycoprotein Antibody Positivity C5139654. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy