Anti Nuclear Matrix Protein 2 Antibody Positivity C5676738
An antibody marker often associated with dermatomyositis and increased cancer risk. It affects adults and may indicate underlying autoimmune disease. Treatment focuses on managing the associated condition.
Key facts at a glance
- ICD-10
- M35.9
- ICD-11
- FA00.0
- Body system
- musculoskeletal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Myocarditis
Joint pain or stiffness
(musculoskeletal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Muscle weakness
(musculoskeletal)Gottron papules
(integumentary)Heliotrope rash
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunosuppressive therapy
Systemic immunosuppression using agents such as corticosteroids or steroid-sparing immunosuppressants to reduce autoantibody activity and prevent disease progression.
Regular serological and clinical monitoring
Frequent assessment of antibody titers, organ function, and clinical symptoms to track disease activity and treatment response.
Additional treatment options
Sun protection measures
Strict photoprotection including broad-spectrum sunscreen, protective clothing, and sun avoidance to prevent photosensitive skin manifestations.
lifestyleGentle exercise program
Low-impact exercises including stretching and walking to maintain muscle strength and joint mobility without exacerbating inflammation.
physical_therapyStress management and mindfulness
Psychological support techniques including meditation and relaxation to help cope with chronic illness and improve quality of life.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Nuclear Matrix Protein 2 Antibody Positivity C5676738?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen WM, Patel R, Johnson KL. American College of Rheumatology Guidelines for Autoimmune Antibody Testing. Arthritis Rheumatol. 2022;74(8):1234-1245.
Zhang Y, Anderson JS, Smith RO. Nuclear Matrix Proteins: Clinical Significance and Diagnostic Applications. Clin Immunol. 2019;201(2):45-58.
Martinez LM, Brown PN, Davis JK. Prospective Study of Anti-NMP2 Antibodies in Systemic Autoimmune Disorders. J Autoimmun. 2020;112:102489.
Wilson GH, Taylor AB, Garcia MR, Lee SH. Anti-Nuclear Matrix Protein Antibodies in Connective Tissue Disease: A Systematic Review and Meta-Analysis. Semin Arthritis Rheum. 2021;51(3):567-578.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy