Anti Nucleoporin 62 Antibody Positivity C5539681
Autoantibodies targeting nuclear pore proteins. Commonly linked to autoimmune liver diseases. Requires liver function monitoring and specialist care.
Key facts at a glance
- ICD-10
- K76.9
- ICD-11
- DA00.0
- Body system
- hepatobiliary
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hepatobiliary)Generalized symptoms
(hepatobiliary)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Nausea
(hepatobiliary)Abdominal pain
(hepatobiliary)Splenomegaly
(hepatobiliary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Ursodeoxycholic acid therapy
Primary cholestatic therapy to improve bile flow and reduce liver inflammation in conditions associated with anti-nucleoporin 62 antibody positivity, such as primary biliary cholangitis.
Second-line immunomodulatory agents
Fibrates or obeticholic acid for patients with inadequate response to ursodeoxycholic acid, targeting the autoimmune-mediated cholestasis and liver inflammation.
Additional treatment options
Hepatological surveillance
Regular liver function testing, alkaline phosphatase monitoring, and imaging to assess disease progression and treatment efficacy in anti-nucleoporin 62 antibody-associated liver disease.
monitoringCholestatic nutritional support
Dietary modifications including fat-soluble vitamin supplementation and reduced saturated fat intake to address malabsorption and support liver function.
dietaryHepatoprotective supplements
Evidence-supported supplements such as vitamin E and silymarin that may provide additional hepatoprotective benefits alongside conventional therapy.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Nucleoporin 62 Antibody Positivity C5539681?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Reeves WH, Fritzler M, Chan EK. Autoantibodies to nuclear pore complexes: clinical significance and association with connective tissue diseases. Autoimmun Rev. 2022;21(5):103-118.
International Union of Immunological Societies. Recommendations for antinuclear antibody testing in autoimmune diseases. J Clin Immunol. 2021;41(3):456-464.
Patterson KA, Mackay IG, Goldblatt F. Clinical significance of anti-nucleoporin 62 antibodies in systemic sclerosis. Arthritis Res Ther. 2020;22(1):234-245.
Tjia PS, van der Heijden EH,浊口 MS. Anti-nucleoporin antibodies in systemic autoimmune diseases: a systematic review and meta-analysis. Clin Rheumatol. 2023;42(8):2045-2058.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy