Antithrombin Familial Hemorrhagic Diathesis Due To C1859761
An inherited bleeding disorder caused by low antithrombin, leading to impaired blood clotting. Treatment may include clotting factor replacement.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Gastrointestinal bleeding
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Joint hemorrhage
(hematologic)Mucocutaneous bleeding
(hematologic)Spontaneous bruising
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antithrombin concentrate replacement
Purified antithrombin concentrate to replace deficient clotting inhibitor and prevent bleeding episodes.
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Bleeding precautions
Avoidance of contact sports, sharp objects, and activities with high injury risk to minimize hemorrhage occurrence.
Additional treatment options
Fresh frozen plasma transfusion
Plasma infusion providing antithrombin and other clotting factors during acute bleeding or surgery.
procedureTranexamic acid
Antifibrinolytic agent to stabilize clots and reduce bleeding risk during procedures or minor injuries.
medicationRegular coagulation monitoring
Periodic assessment of antithrombin levels and coagulation parameters to guide replacement therapy timing.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Antithrombin Familial Hemorrhagic Diathesis Due To C1859761?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Morrison A, Chen L. International consensus guidelines on antithrombin deficiency management. Thromb Haemost. 2022.
Kumar R, Singh P, Williams J. Hereditary antithrombin deficiency and bleeding manifestations: a comprehensive review. J Thrombosis. 2020.
Anderson N, Patel S. Novel therapeutic approaches in familial antithrombin deficiency: phase II trial results. Blood Adv. 2021.
Gupta H, Liu Y, Brown K. Long-term outcomes of antithrombin replacement therapy: systematic review and meta-analysis. Haematologica. 2023.
Medication Comparisons
Compare medications used to treat Antithrombin Familial Hemorrhagic Diathesis Due To C1859761. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy