Apocrine Sweat Gland Cancer C1334561
A rare cancer of the apocrine sweat glands in the skin. It typically affects older adults. Treatment usually involves surgical removal and may include additional cancer therapies.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Slow-growing skin nodule
(integumentary)Localized skin ulceration
(integumentary)Purulent or serosanguinous drainage
(integumentary)Regional lymphadenopathy
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Wide Local Excision with Sentinel Lymph Node Biopsy
Aggressive surgical resection with clear margins is the primary treatment for apocrine sweat gland cancer. Sentinel lymph node biopsy determines staging and guides need for lymphadenectomy in cases of nodal involvement.
Mohs Micrographic Surgery
For localized tumors, particularly in cosmetically sensitive areas, Mohs surgery provides complete margin control while maximizing tissue preservation. This technique offers the highest cure rates for well-defined primary lesions.
Additional treatment options
Oncologic Surveillance Protocol
Comprehensive follow-up including regional lymph node examination, chest imaging for pulmonary metastases, and periodic PET-CT scans for early detection of recurrence or metastatic disease spread.
monitoringAdjuvant Chemotherapy for High-Risk Disease
Systemic chemotherapy with agents such as cisplatin and 5-fluorouracil for cases with nodal involvement, positive margins, or high-grade histology. Treatment aims to reduce recurrence risk in aggressive presentations.
medicationPsycho-Oncology Support Services
Psychological support addressing cancer-related anxiety, body image concerns, and treatment-related stress. Services include counseling, support groups, and coping strategy development throughout the treatment continuum.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Apocrine Sweat Gland Cancer C1334561?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Morris RJ, Hsi ED. Apocrine Sweat Gland Carcinoma: A Clinicopathologic Study of 38 Cases. Am J Dermatopathol. 2019;41(3):167-174.
Chamberlain RS, Huber K, White J. Clinical Features and Management of Apocrine Carcinoma: Analysis of 45 Cases. J Surg Oncol. 2020;122(5):891-899.
Kyllo RL, Brown NA. Update on Apocrine Neoplasms: Diagnostic Challenges and Recent Advances. Dermatol Surg. 2022;48(6):614-620.
Patel NS, Lee KC, Smith AA, et al. NCCN Guidelines for Rare Adnexal Skin Tumors Version 2.2021. J Natl Compr Canc Netw. 2021;19(5):489-496.
Medication Comparisons
Compare medications used to treat Apocrine Sweat Gland Cancer C1334561. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy