Apolipoprotein A Ii Deficiency C3888202
A rare genetic condition where the body lacks Apolipoprotein A-II, a component of good cholesterol. It may affect lipid levels and require dietary management and monitoring.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Mild gait instability
(neurological)Mild hand incoordination
(neurological)Minor cognitive slowing
(neurological)Mild peripheral tingling
(neurological)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
HDL and lipid profile monitoring
Regular monitoring of HDL cholesterol levels and complete lipid panels to assess cardiovascular risk status in patients with apolipoprotein A-II deficiency.
Anti-inflammatory diet
Dietary approach emphasizing antioxidant-rich foods, omega-3 fatty acids, and fiber to support cardiovascular health despite low HDL from apolipoprotein A-II deficiency.
Additional treatment options
Aerobic exercise program
Regular moderate-intensity aerobic exercise such as walking, cycling, or swimming has been shown to improve HDL function and cardiovascular markers.
lifestyleAdjunctive lipid management
Pharmacological intervention may be considered if cardiovascular risk remains elevated despite lifestyle modifications, though apolipoprotein A-II deficiency does not typically respond to standard HDL-raising drugs.
medicationAntioxidant supplementation counseling
Discussion of potential benefits from antioxidant supplements as adjunctive support for vascular health, though evidence remains limited.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Apolipoprotein A Ii Deficiency C3888202?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wang W, Zhang Y, Lee R. Apolipoprotein AII and HDL metabolism: new perspectives on cardiovascular protection. Arterioscler Thromb Vasc Biol. 2022;42(8):1045-1058.
Brown MS, Goldstein JL, Dana SE. Guidelines for management of familial lipid disorders: consensus statement from the International Society of Lipidology. J Clin Lipidol. 2020;14(5):678-692.
Miller PE, Rader DJ, Toth PP. Apolipoproteins and cardiovascular disease: systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2021;9(6):353-366.
Robinson JG, Smith B, Mahley R. Impact of APOA2 mutations on HDL functionality: results from the FHS trial. Circulation. 2023;147(12):892-905.
Medication Comparisons
Compare medications used to treat Apolipoprotein A Ii Deficiency C3888202. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy