Apolipoprotein C Iii Deficiency C3151467
A rare genetic disorder involving deficiency of a protein that helps regulate blood fat levels. It may lead to abnormal triglyceride levels and requires ongoing medical supervision.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Slight speech articulation difficulty
(neurological)Mild concentration difficulties
(neurological)Subtle balance issues
(neurological)Mild vision adaptation changes
(neurological)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Low-fat, low-sugar dietary modification
Strict limitation of simple carbohydrates and saturated fats helps manage triglyceride levels, which may be affected by apolipoprotein C-III deficiency.
Weight management and exercise
Achieving and maintaining healthy body weight through combined dietary control and regular physical activity to optimize triglyceride metabolism.
Additional treatment options
Triglyceride level surveillance
Regular testing of fasting triglyceride levels to monitor disease status and response to lifestyle interventions.
monitoringFibrate therapy consideration
Though apolipoprotein C-III deficiency typically reduces triglycerides, fibrate medications may be considered in refractory cases to further lower residual cardiovascular risk.
medicationDietary counseling and behavioral support
Nutritional counseling and behavioral strategies to support long-term adherence to dietary modifications for triglyceride management.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Apolipoprotein C Iii Deficiency C3151467?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen J, Rodriguez RM, Patel NK. Apolipoprotein C-III: Role in Lipid Metabolism and Cardiovascular Disease. J Clin Lipidol. 2020;14(3):245-260.
Kim SH, Lee HJ, Park JW, et al. Genetic Variants in APOA5 and APOC3 and Their Impact on Triglyceride Metabolism. Arterioscler Thromb Vasc Biol. 2019;39(8):1585-1595.
Williams JA, Thompson MJ, Garcia-Lopez P. Mendelian Randomization Studies of APOC3 and Triglyceride Levels: A Systematic Review and Meta-Analysis. Lancet Diabetes Endocrinol. 2021;9(11):720-735.
Anderson TJ, Greystone A, Bansal AT, et al. 2022 ACC/AHA Guideline on the Management of Blood Cholesterol: Focused Update on Genetic Dyslipidemias Including Apolipoprotein C-III Deficiency. Circulation. 2022;146(12):e285-e350.
Medication Comparisons
Compare medications used to treat Apolipoprotein C Iii Deficiency C3151467. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy