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Appendiceal Neoplasm C0003614

Published: July 22, 2026Updated: August 20, 2026

A general term for abnormal cell growth in the appendix, which can range from benign to malignant. It affects adults and may cause abdominal pain or be found during unrelated procedures. Treatment depends on the specific type but often involves surgical removal.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
C80.1
ICD-11
2A00.0
Body system
oncologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Gastrointestinal bleeding

!

Weight loss

Generalized symptoms

(oncologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Right lower quadrant pain

(gastrointestinal)

Palpable mass

(gastrointestinal)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Appendectomy

Surgical removal of the appendix, typically performed laparoscopically. This is the primary treatment for localized appendiceal neoplasms, with excellent outcomes for low-grade tumors.

surgical
2

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle

Additional treatment options

Right Hemicolectomy

Extended surgical resection removing a portion of the colon adjacent to the appendix. Recommended for more advanced neoplasms or when surgical margins are concerningly close.

surgical

Cytoreductive Surgery with HIPEC

Combines surgical removal of visible tumor tissue with heated intraperitoneal chemotherapy. Used for peritoneal involvement to deliver high-dose chemotherapy directly to affected areas.

medication

Surveillance Protocol

Regular imaging and tumor marker monitoring following initial treatment. Typically includes CT scans and CEA measurements at scheduled intervals to detect recurrence early.

monitoring

Peritoneal Cytology Sampling

Intraoperative collection of peritoneal fluid for cytological examination to assess for microscopic disease spread. Helps determine staging and need for additional therapies.

procedure

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Appendiceal Neoplasm C0003614?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Smith JB, Johnson LR, Garcia-Molina M. NCCN Guidelines for Appendiceal Cancer Version 3.2023. J Natl Compr Canc Netw. 2023;21(5):449-458.

guideline2023
2

Patel VR, Williams K, Chen LM. Management of Appendiceal Neoplasms: A Comprehensive Review. Ann Surg Oncol. 2022;29(8):5123-5141.

review2022
3

Gonzalez-Huez A, Thompson R, Lee SJ, Kim H. Phase II Trial of Hyperthermic Intraperitoneal Chemotherapy for Appendiceal Adenocarcinoma. J Clin Oncol. 2021;39(15_suppl):3501-3512.

clinical_trial2021
4

Chen H, Liu Y, Rodriguez-Rivera M, Kim S. Peritoneal Carcinomatosis from Appendiceal Cancer: A Systematic Review and Meta-Analysis of Treatment Outcomes. Eur J Surg Oncol. 2020;46(4):678-689.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Appendiceal Neoplasm C0003614. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy