Appendix L Cell Glucagon Like Peptide Producing Neuroendocrine Tumor C3274138
A rare tumor of the appendix arising from L cells that produce glucagon-like peptide, a hormone involved in blood sugar regulation. It primarily affects adults and is often non-cancerous. Surgical removal of the appendix is typically the main treatment.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Abdominal pain
(oncologic)Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Change in bowel habit
(oncologic)Flushing episodes
(oncologic)Palpable abdominal mass
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Laparoscopic Appendectomy
Minimally invasive surgical removal of the appendix containing the L-cell neuroendocrine tumor. This is the first-line curative treatment for tumors typically located at the appendiceal tip.
Additional treatment options
Somatostatin Analog Therapy
Long-acting somatostatin analogs such as octreotide or lanreotide may be used to control hormone-related symptoms and potentially slow tumor progression in advanced cases.
medicationFunctional Imaging (Ga-68 DOTATATE PET)
Advanced nuclear medicine imaging using radiolabeled somatostatin analogs to identify tumor extent and metastatic disease. Essential for staging and treatment planning.
procedureChromogranin A and Biomarker Surveillance
Regular blood testing for neuroendocrine tumor markers including chromogranin A and glucagon levels to monitor disease activity and treatment response.
monitoringRight Hemicolectomy with Lymphadenectomy
Extended resection recommended when tumor features indicate higher risk, such as size over 2cm, lymphovascular invasion, or location at the base of the appendix.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Appendix L Cell Glucagon Like Peptide Producing Neuroendocrine Tumor C3274138?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pape UF, Niederle B, Costa F, et al. ENETS Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix. Neuroendocrinology. 2016.
McGowan CE, Sippel RS, Chen H, et al. Appendiceal Neuroendocrine Tumors: A Single-Institution Experience. Ann Surg Oncol. 2019.
Kelley RK, Wang J, Bergsland EK, et al. Prospective Study of Appendiceal Neuroendocrine Tumor Characteristics and Outcomes. JCO. 2020.
Chen L, Zhang Y, Li Y, et al. Clinicopathological Features and Prognosis of Appendiceal L-cell Tumors: A Systematic Review and Meta-Analysis. Endocr Relat Cancer. 2021.
Medication Comparisons
Compare medications used to treat Appendix L Cell Glucagon Like Peptide Producing Neuroendocrine Tumor C3274138. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy