Appendix Neuroendocrine Neoplasm C1879718
A tumor arising from neuroendocrine cells in the appendix, which can produce hormones and occur with varying aggressiveness. It primarily affects middle-aged adults and is often found incidentally during surgery for other conditions. Surgical removal of the appendix is usually curative when localized.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Abdominal pain
(oncologic)Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Change in bowel habit
(oncologic)Unintentional weight loss
(oncologic)Flushing episodes
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Appendectomy with Staging
Surgical removal of the appendix with comprehensive intraoperative staging including lymph node sampling and peritoneal washings. Standard first-line treatment for localized disease.
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Additional treatment options
Peptide Receptor Radionuclide Therapy (PRRT)
Targeted radiation therapy using radiolabeled somatostatin analogs to treat metastatic neuroendocrine tumors. Delivered intravenously over multiple sessions.
medicationMultidisciplinary Surveillance Program
Long-term follow-up program involving imaging, biochemical markers, and clinical assessment. Frequency adjusted based on tumor grade and stage at diagnosis.
monitoringDiagnostic Laparoscopy with Staging
Minimally invasive surgical exploration to assess disease extent, obtain tissue samples, and evaluate peritoneal involvement when non-invasive imaging is inconclusive.
procedureNutritional Support and Symptom Management
Supportive care addressing hormone-related symptoms such as diarrhea and flushing through dietary modifications and targeted supportive medications.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Appendix Neuroendocrine Neoplasm C1879718?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pape UF, Niederle B, Costa F, et al. ENETS Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix. Neuroendocrinology. 2016;103(2):123-131.
McGory ML, Maggard MA, Kang H, et al. Adverse Outcomes in Appendiceal Carcinoid Tumors: A Population-Based Study. J Am Coll Surg. 2007;204(5):895-901.
Muller SA, Pahernik S, Hinz U, et al. Prognostic Factors and Long-Term Outcome After Surgical Treatment of Appendiceal Neuroendocrine Tumors. Ann Surg Oncol. 2021;28(8):4549-4559.
Groen EL, van de Winkel JG, van der Zwan ER, et al. Appendiceal Neuroendocrine Tumors: A Systematic Review and Meta-Analysis of Surgical Approaches. Eur J Surg Oncol. 2023;49(4):752-761.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy