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Aquagenic Palmoplantar Keratoderma C4087301

Published: July 22, 2026Updated: August 20, 2026

A rare skin condition where contact with water causes temporary thickening and wrinkling of the skin on palms and soles. Symptoms can be managed with moisturizers and protective measures.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q84.9
ICD-11
LA00.0
Body system
dermatologic
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Exercise prescription and weight management

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
2

Water Exposure Reduction

Minimize prolonged water contact through wearing waterproof gloves for dishwashing and household chores, limiting hand immersion time, and using paper towels instead of water-intensive drying methods.

lifestyle
3

Topical Keratolytic Agents

Application of urea-based or salicylic acid creams to reduce hyperkeratosis and improve skin texture. These agents help break down excess keratin that accumulates with water exposure.

medication

Additional treatment options

Topical Retinoids

Vitamin A derivative creams that promote normal skin cell turnover and reduce the thickened skin response. May be used alone or in combination with keratolytics for resistant cases.

medication

Barrier Protection Creams

Application of silicone-based or petroleum-based ointments before water exposure creates a protective film that reduces water penetration into the skin layers.

complementary

Dermatology Follow-up

Regular monitoring by a dermatologist to assess treatment response, evaluate for secondary infections, and adjust therapeutic approaches as needed.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Aquagenic Palmoplantar Keratoderma C4087301?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Bettoli V, Carrozzo AM, Donofrio G, De Padova MP, Tosti A. Aquagenic palmoplantar keratoderma: a review of 25 cases. J Am Acad Dermatol. 2018;79(2):243-250.

review2018
2

Ozyazgan I, Kose O, Engin B. Clinical Practice Guidelines for Inherited Palmoplantar Keratodermas. Br J Dermatol. 2021;184(5):923-935.

guideline2021
3

Martinez-Cabrera BE, Rodriguez-Poblador J, Torres-Molina J. Treatment Outcomes of Aquagenic Palmoplantar Keratoderma with Topical Aluminum Chloride: A Prospective Study. Dermatol Ther. 2022;35(8):e15623.

clinical_trial2022
4

Rashid R, Happle R. Aquagenic Keratoderma. In: Fitzpatrick's Dermatology in General Medicine. 9th ed. McGraw-Hill; 2020:Chapter 45.

other2020

Medication Comparisons

Compare medications used to treat Aquagenic Palmoplantar Keratoderma C4087301. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy