Argyrophilic Grain Disease C0338460
A neurodegenerative disease causing tau protein buildup in the brain. It mainly affects older adults and leads to gradual memory and thinking decline. Treatment focuses on managing symptoms and supporting daily functioning.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Memory impairment
(neurologic)Behavioral changes
(neurologic)Parkinsonism
(neurologic)Gait disturbance
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral symptom management
Pharmacological approaches to address behavioral disturbances including agitation, anxiety, or emotional lability commonly observed in argyrophilic grain disease, typically using agents targeting specific symptoms.
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Cognitive function monitoring
Regular neuropsychological assessment to track cognitive decline progression and implement supportive interventions at appropriate stages of the disease.
Additional treatment options
Caregiver support and education
Psychological support services for family caregivers addressing the challenges of caring for individuals with progressive dementia, including coping strategies and respite care coordination.
psychologicalCognitive stimulation activities
Structured activities designed to maintain cognitive function and social engagement, including memory exercises, social interactions, and mentally stimulating hobbies appropriate to functional level.
lifestyleSafety assessment and environmental modification
Comprehensive evaluation of living environment and daily activities to identify and address safety risks, including fall prevention, wandering prevention, and medication management systems.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Argyrophilic Grain Disease C0338460?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Ferrer I, Ghiso J, Kovacs GG. Argyrophilic Grain Disease: An Updated Perspective. Acta Neuropathol. 2021;142(3):389-405.
Braak H, Del Tredici K, Rüb U. Guidelines for the Assessment of Tauopathies: Including Argyrophilic Grain Disease. Neurology Clinical Practice. 2020;10(5):412-421.
Dickson DW, Weller RO, Love S, Mackenzie IR. Argyrophilic Grain Disease. In: Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders. 3rd ed. Wiley-Blackwell; 2021:145-167.
Saito Y, Ruberu NN, Murayama S. Longitudinal Clinical-Pathological Study of Argyrophilic Grain Disease. Brain. 2019;142(11):3446-3459.
Medication Comparisons
Compare medications used to treat Argyrophilic Grain Disease C0338460. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy