Atypical Hemolytic Uremic Syndrome C3 Glomerulopathy Cn380068
A disorder causing inflammation and scarring in the kidney filters due to immune system dysfunction. It can lead to kidney failure over time. Immunosuppressive medications and kidney care are mainstays of treatment.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Microangiopathic hemolytic anemia
Stroke and focal neurological deficits
Myocardial infarction
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Declining glomerular filtration rate
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Complement C5 Inhibitor Therapy
Targeted inhibition of terminal complement pathway to prevent complement-mediated endothelial injury in the glomeruli. Standard first-line therapy for C3 glomerulopathy presenting with aHUS features.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Plasma Exchange Therapy
Removes pathogenic complement-fixing antibodies and replaces functional complement regulatory proteins. Often used as adjunctive therapy or when complement inhibitors are unavailable.
Additional treatment options
Corticosteroid Therapy
High-dose corticosteroids to reduce inflammation and complement activation. May serve as bridge therapy while awaiting response to targeted agents.
medicationRenal Function and Complement Biomarker Surveillance
Systematic tracking of serum creatinine, proteinuria, C3/C4 levels, and hematologic markers to guide treatment duration and detect subclinical disease activity.
monitoringRenal-Protective Diet
Balanced nutritional approach limiting processed foods, controlling protein quantity, and ensuring adequate hydration to reduce glomerular stress.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Atypical Hemolytic Uremic Syndrome C3 Glomerulopathy Cn380068?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Goodship TH, Cook HT, Fakhouri F, et al. Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2017.
Noris M, Remuzzi G. Atypical hemolytic-uremic syndrome. N Engl J Med. 2009;361(17):1676-1687.
Legendre CM, Licht C, Muus P, et al. Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med. 2013;368(23):2169-2181.
Smith RJ, Harris CL, Pickering MC. C3 glomerulopathy. Immunol Rev. 2011;223(1):207-219.
Medication Comparisons
Compare medications used to treat Atypical Hemolytic Uremic Syndrome C3 Glomerulopathy Cn380068. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy