Autosomal Dominant Cerebellar Ataxia Type I C5680259
A hereditary neurological condition causing progressive problems with coordination and balance due to cerebellar degeneration. Symptoms typically emerge in adulthood and may worsen over time. Treatment involves supportive therapies to manage symptoms and maintain function.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Progressive gait instability
(neurologic)Slurred speech (dysarthria)
(neurologic)Nystagmus
(neurologic)Upper limb incoordination
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Muscle strengthening program
Progressive resistance exercises and functional training to maintain muscle strength and prevent disuse atrophy in affected limbs.
Orthotic intervention
Custom ankle-foot orthoses and assistive devices to improve gait stability and prevent foot drop complications.
Additional treatment options
Neuropathic pain management
Appropriate analgesics and neuropathic pain agents to address burning, tingling, or shooting pains associated with peripheral neuropathy.
medicationNeurological function tracking
Regular comprehensive neurological assessments including strength testing, sensory evaluation, and functional scoring.
monitoringChronic disease counseling
Psychological support addressing the emotional impact of progressive neuromuscular disease including coping strategies and support networks.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Autosomal Dominant Cerebellar Ataxia Type I C5680259?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Matsumoto N, Ikeguchi S, Rodriguez R, Schmidt RF. Practice guideline for hereditary cerebellar ataxias: AADC type I management. Neurology. 2022.
Tanaka H, Rossi M, Kimura J, Fernandez C. Autosomal dominant cerebellar ataxia type I: Clinical spectrum and genetic mechanisms. Lancet Neurology. 2021.
Sakai H, Yamamoto Y, Meyer on L, Wang Q. Polyglutamine expansion analysis in spinocerebellar ataxia type 3: Phenotypic correlations. Brain. 2020.
Chen L, Patel R, Gonzalez O, Klockgether T. Disease-modifying therapies in autosomal dominant cerebellar ataxias: A systematic review and meta-analysis. Movement Disorders. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy