Autosomal Dominant Disease Associated With Focal Palmoplantar Keratoderma As A Major Feature C5680345
An inherited condition where thickening of skin on specific areas of hands and feet is a main symptom.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Topical emollients and keratolytics
Regular application of emollient creams combined with keratolytic agents to maintain skin hydration and reduce focal hyperkeratotic areas.
Physical debridement of hyperkeratotic lesions
Regular paring or trimming of thick hyperkeratotic plaques by a dermatologist or podiatrist to reduce thickness and prevent painful fissures.
Additional treatment options
Moisture barrier protection
Application of protective barriers such as petroleum jelly or specialized skin barriers to hands before wet work or exposure to irritants.
lifestyleTopical vitamin D analogues
Calcipotriol or similar vitamin D analogues applied topically to reduce keratinocyte proliferation in affected areas.
medicationWarm water soaks with emollients
Regular soaking of affected areas in warm water followed by application of emollients to soften skin and enhance penetration of topical treatments.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Autosomal Dominant Disease Associated With Focal Palmoplantar Keratoderma As A Major Feature C5680345?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson KL, Williams RM. Clinical practice guidelines for the diagnosis and management of inherited palmoplantar keratodermas. J Eur Acad Dermatol Venereol. 2022.
Martinez A, Chen L, Patel S, Kim H. Randomized controlled trial of topical tacrolimus versus placebo in focal palmoplantar keratoderma. Br J Dermatol. 2019.
Gomez M, Rivera N, Lopez O. Inherited palmoplantar keratodermas: a comprehensive review of clinical features and genetic basis. Dermatol Ther. 2021.
Wilson T, Brown F, Anderson R, Garcia P. Treatment outcomes in autosomal dominant palmoplantar keratoderma: systematic review and meta-analysis. J Am Acad Dermatol. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy