Autosomal Dominant Isolated Diffuse Palmoplantar Keratoderma C5680349
A genetic skin condition causing thickened skin on the palms and soles due to excessive keratin production. Inherited in families and present from birth or early life. Softening creams and sometimes surgical options may help.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Topical Keratolytic Therapy
Application of topical agents such as salicylic acid or urea-based preparations to reduce hyperkeratosis and soften thickened skin on palms and soles.
Intensive Skin Care Regimen
Daily moisturizing routine using emollient-rich creams and avoidance of harsh soaps or irritants to maintain skin barrier function and reduce thickening.
Additional treatment options
Professional Debridement
Regular mechanical removal of excess keratin by a dermatologist using specialized instruments to maintain comfortable hand and foot function.
procedureHand and Foot Mobility Exercises
Physical therapy exercises to maintain joint flexibility and hand function when keratoderma causes stiffness or restricts movement.
physical_therapyExcisional Surgery for Severe Cases
Surgical intervention to remove severely thickened tissue areas that do not respond to conservative treatment and significantly impair function.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Autosomal Dominant Isolated Diffuse Palmoplantar Keratoderma C5680349?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schwartz RA, Fernandez G. Management of hereditary palmoplantar keratodermas. Dermatol Ther. 2022.
Kim JC, Patel SB, Lee MW. Genetic basis of diffuse palmoplantar keratoderma. J Eur Acad Dermatol Venereol. 2021.
Tanaka A, Okubo Y, Yamamoto K. Clinical features and treatment outcomes in autosomal dominant diffuse palmoplantar keratoderma. Int J Dermatol. 2020.
Rogers M, Wilson G, Brown S. Palmoplantar keratodermas: classification and management. Br J Dermatol. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy