Autosomal Dominant Medullary Cystic Kidney Disease With Or Without Hyperuricemia C4511620
A hereditary kidney disorder causing cysts to form in the kidney medulla. It may lead to reduced kidney function and sometimes elevated uric acid. Management includes monitoring kidney health and addressing complications.
Key facts at a glance
- ICD-10
- Q61.5
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Polyuria
(renal)Hypertension
(cardiovascular)Nocturia
(renal)Flank pain
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Renal Function Surveillance
Regular monitoring of kidney function through serum creatinine, estimated glomerular filtration rate, and urinalysis to track disease progression.
Blood Pressure Management
Control of hypertension using appropriate antihypertensive approaches to protect remaining kidney function.
Additional treatment options
Kidney-Protective Dietary Modifications
Sodium restriction, moderate protein intake, and adequate hydration to reduce kidney workload and slow disease progression.
dietaryHyperuricemia Management
Treatment of elevated uric acid levels when present, using approaches appropriate for patients with underlying kidney disease.
medicationNephrotoxic Exposure Avoidance
Avoidance of substances that can harm kidneys including certain medications, excessive NSAIDs, and contrast dyes when possible.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Autosomal Dominant Medullary Cystic Kidney Disease With Or Without Hyperuricemia C4511620?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kidney Disease: Improving Global Outcomes (KDIGO). Clinical Practice Guideline for the Management of Genetic Kidney Diseases. Kidney Int. 2023.
Eckardt KU, Alper SL, Antignac C, et al. Autosomal Dominant Tubulointerstitial Kidney Disease: Diagnosis, Classification, and Management. Nat Rev Nephrol. 2022.
Olinger E, Hofmann A, Kipp K, et al. Clinical and Genetic Characterization of Families with UMOD Mutations. Clin J Am Soc Nephrol. 2020.
Devuyst O, Kmoch S, Bleyer AJ. Uromodulin and the Pathophysiology of Autosomal Dominant Tubulointerstitial Kidney Disease. Nephrol Dial Transplant. 2021.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy