Skip to content

Autosomal Dominant Mitochondrial Myopathy With Exercise Intolerance C4015513

Published: July 22, 2026Updated: August 20, 2026

A genetic muscle disorder caused by faulty mitochondria, the energy producers in cells. It causes fatigue, weakness, and exercise intolerance, often appearing in young adults. Treatment focuses on pacing and supportive care.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q79.9
ICD-11
LA00.0
Body system
musculoskeletal
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Exercise intolerance

(musculoskeletal)

Joint pain or stiffness

(musculoskeletal)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Muscle fatigue after mild activity

(musculoskeletal)

Ptosis (drooping eyelids)

(musculoskeletal)

Peripheral neuropathy

(musculoskeletal)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Dietary counseling and physical activity plan

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Paced exercise program

Individualized low-intensity exercise program with frequent rest periods designed to accommodate mitochondrial dysfunction and prevent post-exercise fatigue. Exercise tolerance is carefully monitored and adjusted based on patient response.

lifestyle
3

Mitochondrial support nutrition

Dietary approach emphasizing foods rich in antioxidants and B-vitamins to support mitochondrial function, with emphasis on complex carbohydrates and lean proteins while avoiding prolonged fasting periods.

dietary

Additional treatment options

CoQ10 supplementation

Coenzyme Q10 supplementation to support mitochondrial electron transport chain function and potentially improve muscle energy metabolism in patients with mitochondrial myopathy.

medication

Muscle conditioning therapy

Physical therapy focusing on gentle strengthening exercises and range of motion maintenance to preserve muscle function and prevent deconditioning while avoiding overexertion.

physical_therapy

Cardiac and metabolic monitoring

Regular cardiac evaluations including echocardiogram and metabolic panels to monitor for cardiac involvement and disease progression in mitochondrial myopathy patients.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Autosomal Dominant Mitochondrial Myopathy With Exercise Intolerance C4015513?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Mitochondrial Medicine Society, Neurological Disorders Working Group. Practice Guidelines for Mitochondrial Myopathies. Neuromuscul Disord. 2022.

guideline2022
2

Garcia-Ramos GS, Lopez-Hidalgo JC, Park JM. Mitochondrial Myopathies: Clinical Features and Molecular Mechanisms. Muscle Nerve. 2021.

review2021
3

Nakamura K, Thompson SR, Peters BR, Rivera CJ. Efficacy of Coenzyme Q10 Supplementation in Mitochondrial Myopathy Patients: A Randomized Controlled Trial. J Clin Invest. 2020.

clinical_trial2020
4

Fernandez-Burriel M, Delmonte M, Santos-Ocaña C. Exercise Intolerance in Mitochondrial Disorders: A Systematic Review and Meta-Analysis. Orphanet J Rare Dis. 2023.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Autosomal Dominant Mitochondrial Myopathy With Exercise Intolerance C4015513. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy