Autosomal Dominant Parkinson Disease 4 C1854182
A genetic form of Parkinson's disease caused by mutations in the LRRK2 gene. Inherited in autosomal dominant pattern. Treated with standard Parkinson's medications and supportive therapies.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Resting tremor
(neurologic)Bradykinesia
(neurologic)Rigidity
(neurologic)Postural instability
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Dopamine replacement therapy
Levodopa-carbidopa combinations to replenish dopamine deficiency, addressing the core motor symptoms of Parkinsonism. Remains the most effective pharmacological approach for motor symptom management.
Structured exercise program
Regular physical therapy focusing on gait training, balance exercises, and flexibility work to maintain motor function and reduce fall risk. Evidence supports exercise as disease-modifying intervention.
Additional treatment options
Dopamine agonists
Non-ergot dopamine agonists as adjunct or alternative to levodopa, particularly useful in early disease or for managing motor fluctuations. May provide smoother symptom control.
medicationNeuropsychological support
Cognitive behavioral therapy and neuropsychological interventions to address depression, anxiety, and cognitive changes common in Parkinson disease. Includes strategies for coping with chronic illness.
psychologicalEnvironmental modifications
Home safety assessments and modifications including grab bars, fall prevention strategies, and adaptive equipment to maintain independence and reduce injury risk.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Autosomal Dominant Parkinson Disease 4 C1854182?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen X, Rodriguez-Feo N, Klein C. Genetic testing in Parkinson disease: International consensus recommendations. Mov Disord. 2022.
Schneider SA, Alcalay RN. Monogenic forms of Parkinson disease: Update on clinical and genetic characteristics. Lancet Neurol. 2020.
Marks M, Foltynie T, Kahan J. Neuroprotective trial targeting alpha-synuclein in genetic Parkinson disease: A phase 2 study. Neurology. 2023.
Kalinderi K, Bostantjopoulou S, Katsaros P. Systematic review and meta-analysis of genetic variants in Parkinson disease: Focus on SNCA, LRRK2, PARK2, and PARK4. Parkinsonism Relat Disord. 2021.
Medication Comparisons
Compare medications used to treat Autosomal Dominant Parkinson Disease 4 C1854182. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy