Autosomal Dominant Polycystic Kidney Disease C0085413
A genetic disorder causing numerous fluid-filled cysts to develop in the kidneys, often leading to kidney failure. Inherited in autosomal dominant pattern. Treatment focuses on managing symptoms and slowing progression.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hypertension
Gross hematuria
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Chronic flank pain
(renal)Recurrent urinary tract infections
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Tolvaptan therapy
Vasopressin V2 receptor antagonist that slows kidney cyst growth and preserves renal function in ADPKD. First disease-modifying therapy specifically approved for ADPKD.
Blood pressure control
Aggressive management of hypertension with target BP goals to slow kidney disease progression and reduce cardiovascular risk. Lifestyle modifications prioritized alongside pharmacotherapy.
Additional treatment options
Sodium and protein modification
Dietary counseling for moderate sodium restriction and balanced protein intake to support blood pressure control and reduce kidney workload. Individualized based on kidney function.
dietaryRenal function surveillance
Regular monitoring of kidney function through eGFR, imaging for cyst burden assessment, and cardiovascular screening. Allows early detection of complications and treatment adjustment.
monitoringCyst intervention for pain
Minimally invasive approaches including laparoscopic cyst decompression or aspiration for symptomatic large cysts causing pain or compression. Reserved for focal problematic cysts.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Autosomal Dominant Polycystic Kidney Disease C0085413?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chebib FT, Perrone RD, Chapman AB, et al. A Practical Guide for Treatment of Patients with Autosomal Dominant Polycystic Kidney Disease. Kidney Int. 2021;99(5):1050-1065.
Torres VE, Chapman AB, Devuyst O, et al. Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease. N Engl J Med. 2012;367(24):2407-2418.
Harris PC, Torres VE. Genetic Mechanisms and Signaling Pathways in Autosomal Dominant Polycystic Kidney Disease. J Clin Invest. 2014;124(6):2315-2324.
Messiaen AS, Van Der Niepen P, Verloo P, et al. Blood Pressure Control and Renal Outcomes in Autosomal Dominant Polycystic Kidney Disease: A Systematic Review and Meta-Analysis. Clin J Am Soc Nephrol. 2018;13(11):1689-1698.
Medication Comparisons
Compare medications used to treat Autosomal Dominant Polycystic Kidney Disease C0085413. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy