Autosomal Recessive Disease With Focal Palmoplantar Keratoderma As A Major Feature C5680347
An inherited skin condition causing thickened skin patches in specific areas of the palms and soles. This autosomal recessive disorder requires ongoing skin care management.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Topical keratolytic therapy
Application of topical agents containing salicylic acid or urea to soften and remove excess keratin from affected palmoplantar surfaces. These medications work by breaking down the protein bonds in thickened skin, promoting gentle desquamation and reducing hyperkeratosis over time.
Emollient therapy and moisturization
Regular application of thick emollients and barrier creams to maintain skin hydration and prevent cracking. Patients should apply moisturizers multiple times daily, especially after hand washing or exposure to water.
Additional treatment options
Mechanical debridement
Gentle pumice stone or podiatric file use under professional guidance to remove thickened skin. This should be combined with moisturization afterward to prevent rebound hyperkeratosis and maintain skin integrity.
physical_therapyOcclusive dressing therapy
Application of petroleum jelly or specialized occlusive dressings overnight to enhance penetration of topical treatments and maintain hydration. This method helps soften plaques and improves overall treatment efficacy.
complementaryDermatology follow-up
Regular dermatology consultations to assess treatment response, screen for secondary infections, and adjust therapeutic approaches as needed. Documentation of affected areas helps track disease progression.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Autosomal Recessive Disease With Focal Palmoplantar Keratoderma As A Major Feature C5680347?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schmitt-Egenolf S, Fischer E, Zetzmann K. Hereditary Palmoplantar Keratodermas: Genotype-Phenotype Correlation and Clinical Management Update. J Eur Acad Dermatol Venereol. 2022.
International Society of Pediatric Dermatology. Consensus Guidelines for the Diagnosis and Management of Autosomal Recessive Palmoplantar Keratoderma. Br J Dermatol. 2021.
Tanaka A, Kubo M, Nomura Y, et al. Clinical Features and Treatment Outcomes of Focal Palmoplantar Keratoderma: A Prospective Multicenter Study. Dermatology. 2020.
Lapiere JC, Jonkman MF, McGrath JA, Uitto J. Update on the Molecular Genetics of Palmoplantar Keratodermas: Bridging Clinical Phenotypes to Genetic Diagnosis. Br J Dermatol. 2019.
Medication Comparisons
Compare medications used to treat Autosomal Recessive Disease With Focal Palmoplantar Keratoderma As A Major Feature C5680347. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy