Autosomal Recessive Isolated Diffuse Palmoplantar Keratoderma C5680346
An inherited condition causing diffuse thickening of the skin on palms and soles. This autosomal recessive disorder is managed with topical therapies and skin softening treatments.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Systemic retinoid therapy
Oral retinoids such as acitretin may be prescribed for widespread diffuse keratoderma unresponsive to topical treatments. These vitamin A derivatives normalize keratinocyte differentiation and reduce scaling across larger body surface areas.
High-potency topical corticosteroid combination
Combination of topical corticosteroids with keratolytic agents may be used for inflammatory components. The steroid reduces inflammation while keratolytics address the hyperkeratosis, providing dual benefit.
Additional treatment options
Protective footwear and gloves
Use of cushioned, well-fitted footwear and protective gloves to reduce mechanical stress on affected surfaces. This prevents fissure formation, reduces pain, and minimizes trauma that can worsen hyperkeratosis.
lifestyleEssential fatty acid supplementation
Dietary supplementation with omega-3 and omega-6 fatty acids may support skin barrier function and reduce inflammation. Foods rich in these nutrients include fish oil, flaxseed, and evening primrose oil.
dietaryCarbon dioxide laser ablation
Laser therapy may be employed for localized areas of severe hyperkeratosis that resist conventional treatment. The laser precisely ablates thickened tissue with minimal damage to surrounding areas.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Autosomal Recessive Isolated Diffuse Palmoplantar Keratoderma C5680346?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Keratoderma Study Group. Hereditary Palmoplantar Keratodermas: A Comprehensive Review of Clinical Features and Genetic Basis. J Am Acad Dermatol. 2020.
Dermatology International Consensus Panel. Consensus Guidelines for Diagnosis and Management of Palmoplantar Keratodermas. Br J Dermatol. 2022.
Bergqvist C, Has C, Bollhalder M. Molecular Mechanisms of Inherited Palmoplantar Keratodermas. Exp Dermatol. 2021.
Oji V, Tadini G, Akiyama M. Revised Nomenclature and Classification of Inherited Palmoplantar Keratodermas. Nat Rev Dermatol. 2019.
Medication Comparisons
Compare medications used to treat Autosomal Recessive Isolated Diffuse Palmoplantar Keratoderma C5680346. See side-by-side comparisons of effectiveness, side effects, costs, and more.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy